Author | Pereira, Felicidade Mota | |
Author | Ramos, Pablo Ivan Pereira | |
Author | Lirio, Monique | |
Author | Atta, Ajax Mercês | |
Author | Oliveira, Isabela Silva de | |
Author | Nascimento, Fabio Carneiro Vosqui | |
Author | Silva, Marcelo Costa | |
Author | Castro Filho, Bernardo Galvão | |
Author | Grassi, Maria Fernanda Rios | |
Access date | 2021-04-20T12:24:37Z | |
Available date | 2021-04-20T12:24:37Z | |
Document date | 2021 | |
Citation | PEREIRA, Felicidade Mota et al. Evaluation of the Inflammatory Cytokines and IL-10 Network in Individuals Co-infected With Human T-Cell Lymphotropic Virus and Hepatitis C Virus (HTLV/HCV). Frontiers in Microbiology, fev. 2021. | pt_BR |
ISSN | 1664-302X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/46776 | |
Sponsorship | Coordination of Superior
Level Staff Improvement – Brazil (CAPES) – Finance
Code 001 and National Foundation for the Development
of Private Higher Education (FUNADESP), grants
9600140, and 9600141. MG and BG-C are research
fellows of CNPq (process nos. 304811/2017-3s and
311054/2014-5, respectively). | pt_BR |
Language | eng | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | HTLV | pt_BR |
Subject in Portuguese | Hepacivirus | pt_BR |
Subject in Portuguese | Coinfecção | pt_BR |
Subject in Portuguese | Citocinas | pt_BR |
Title | Evaluation of the Inflammatory Cytokines and IL-10 Network in Individuals Co-infected With Human T-Cell Lymphotropic Virus and Hepatitis C Virus (HTLV/HCV) | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fmicb.2021.632695 | |
Abstract | Co-infection between the human T-cell lymphotropic virus (HTLV) and
the hepatitis C virus (HCV) can modify the natural history of HCV infection. The aim of
this study was to describe the inflammatory cytokines and IL-10 network in patients
co-infected with HTLV and HCV viruses in Bahia, Brazil.
Methods: Samples from 31 HTLV/HCV co-infected individuals and 27 HCV
monoinfected individuals were evaluated. IFN-g, TNF-a, IL-10, IL-8, and IL-1 cytokines
were quantified by ELISA. Clinical, laboratory data were obtained from patient records.
Serum levels of the cytokines were log10-transformed and data mining was performed
using Z-score statistics and correlation analysis.
Results: Co-infected individuals presented a tendency toward higher production of INF-
g compared to the HCV monoinfected group. Regarding cytokine pairs, there was a
positive correlation (P-value < 0.05) between IL-1 and IL-8 in the HTLV/HCV co-infected
group and uninfected controls, and two correlations in the HCV mono-infected group
IL-8 – IL10 and IL- INF-g – IL-10 pairs. There was no significant difference between the
groups for the other parameters analyzed.
Conclusion: The results presented herein indicated that HTLV/HCV co-infection was
associated with a trend in IFN-g production while HCV-infected individuals presented
a positive correlation with both inflammatory cytokines (IL-8 and IFN-g) and the
regulatory cytokine IL-10. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Secretaria da Saúde do Estado da Bahia. Laboratório Central de Saúde Pública Prof. Gonçalo Moniz. Salvador, Bahia, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Secretaria Municipal de Saúde de Feira de Santana. Feira de Santana, BA, Brasil. | pt_BR |
Affilliation | Secretaria da Saúde do Estado da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Subject | HTLV | pt_BR |
Subject | HCV | pt_BR |
Subject | Co-infection | pt_BR |
Subject | Network | pt_BR |
Subject | Cytokines | pt_BR |