Author | Martins, Caroline Azevedo | |
Author | Santos, Maria Conceição B dos | |
Author | Albuquerque, Cassiano Felippe Gonçalves de | |
Author | Faria Neto, Hugo Caire Castro | |
Author | Faria, Mauro Velho Castro | |
Author | Burth, Patricia | |
Author | Younes-Ibrahim, Mauricio | |
Access date | 2021-04-16T19:50:32Z | |
Available date | 2021-04-16T19:50:32Z | |
Document date | 2021 | |
Citation | MARTINS, Caroline Azevedo et al. The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis. Helyon, v. 7, e06430, 7p, Mar. 2021. | pt_BR |
ISSN | 2405-8440 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/46743 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Resultado clínico da Leptospirose | pt_BR |
Subject in Portuguese | Lipotoxicidade aguda | pt_BR |
Subject in Portuguese | Lipidome | pt_BR |
Subject in Portuguese | Ácido oleico/albumina | pt_BR |
Subject in Portuguese | Na/K-ATPase | pt_BR |
Title | The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.heliyon.2021.e06420 | |
Abstract | Human leptospirosis is an acute infectious zoonosis presenting specific lipid disorders. Previous in vitro studies
showed both leptospira glycolipoprotein endotoxin, and high oleic acid levels were associated with Na/K-ATPase
inhibition that is amplified by the reduction of circulating albumin levels. In this study, we aimed to investigate
the relationship of oleic acid/albumin (OA/A) molar ratio and clinical outcomes in Leptospirosis. Through a
prospective observational cohort study employing high-performance liquid chromatography (HPLC) we sequen tially determined serum concentrations of nonesterified fatty acids (NEFA) and albumin in twenty-eight patients
with severe leptospirosis since their hospital admission. Twenty patients recovered, and eight died. Data was
distributed in two groups according to clinical outcomes. Oleic acid/albumin molar ratios (OA/A), initial samples,
were higher than those in healthy donors. The ratio OA/A, however, persisted high in dying patients, whereas
patients who survived had a reduction matching to healthy donors. Biochemical alterations suggest that cure is
correlated to the reestablishment of the OA/A molar ratio, while fatal outcomes related to persisting OA/A im balances. Analysis by receiver operating characteristic (ROC) showed the area under the curve of 0.864 and the
cutoff value of 0.715 being associated with a high odds ratio. Lipid analysis from patients with leptospirosis had
an acute high serum OA/A molar ratio, and sustained imbalance has a high odds ratio and strong correlation with
mortality. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Medicina Interna. Laboratório Integrado de Nefrologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Medicina Interna. Laboratório Integrado de Nefrologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Bioquímica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | niversidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Medicina Interna. Laboratório Integrado de Nefrologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Biologia Celular e Molecular. Laboratório de Enzimologia e Sinalização Celular. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Medicina Interna. Laboratório Integrado de Nefrologia. Rio de Janeiro, RJ, Brasil / Pontifícia Universidade Católica. Departamento de Medicina. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Leptospirosis clinical outcome | pt_BR |
Subject | Acute lipotoxicity | pt_BR |
Subject | Lipidome | pt_BR |
Subject | Oleic acid/albumin | pt_BR |
Subject | Na/K-ATPase | pt_BR |