| Author | Oliveira, Maria Rayane Correia de | |
| Author | Silva, Maria Gabriely de Lima | |
| Author | Alcântara, Isabel Sousa | |
| Author | Ribeiro Filho, Jaime | |
| Author | Tintino, Cícera Datiane de Morais Oliveira | |
| Author | Magalhães, Francisco Ernani Alves | |
| Author | Martins, Anita Oliveira Brito Pereira Bezerra | |
| Author | Pessoa, Renata Torres | |
| Author | Duarte, Antonia Eliene | |
| Author | Costa, José Galberto Martins da | |
| Author | Lima, Sidney Gonçalo de | |
| Author | Coutinho, Henrique Douglas Melo | |
| Author | Capasso, Raffaele | |
| Author | Menezes, Irwin Rose Alencar de | |
| Access date | 2021-04-09T13:51:39Z | |
| Available date | 2021-04-09T13:51:39Z | |
| Document date | 2021 | |
| Citation | OLIVEIRA, Maria Rayane Correia de et al. Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice. Environment, Development and Sustainability, 2021. | pt_BR |
| ISSN | 1387-585X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/46589 | |
| Description | Ribeiro Filho, Jaime. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. “Documento protegido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
| Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível
Superior—Brasil (CAPES)—Finance Code 001, Fundação Cearense de Apoio ao Desenvolvimento Científico
e Tecnológico (FUNCAP)—Finance Code BPI and Conselho Nacional de Desenvolvimento Científico
e Tecnológico (CNPq) and Financiadora de Estudos e Projetos—Brasil (FINEP). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Springer | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Lantana | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Ácido Araquidônico | pt_BR |
| Subject in Portuguese | Histamina | pt_BR |
| Subject in Portuguese | Camundongos | pt_BR |
| Title | Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice | pt_BR |
| Type | Article | pt_BR |
| Abstract | This work aimed to analyze the chemical composition and evaluate the anti-inflammatory
and antinociceptive properties of the essential oil obtained from the leaves of Lantana
montevidensis (OEFLM) in mice. The chemical composition of the OEFLM was analyzed
by GC–MS, and its effects on the central nervous system were determined by the open field
and rotarod tests. The antinociceptive and anti-inflammatory screenings were conducted
using the formalin test, as well as the acetic acid-induced abdominal contortion assay. The
antinociceptive activity was assessed by the tail-flick and hot plate tests. The systemic
anti-inflammatory activity was determined using models of paw edema induced by carrageenan,
dextran, histamine, or arachidonic acid. The effects of the essential oil on vascular
permeability and granuloma formation were also investigated. The chemical composition
of the OEFLM revealed the presence of valencene (17.93%), bicyclogermacrene (16.35%),
trans-caryophyllene (12.84%) and germacrene D (12.18%). The administration of OEFLM
at the dose of 2000 mg/Kg caused no evident toxicity. While OEFLM (25, 50, 100, and
200 mg/kg) did not present significant anxiolytic-loke or sedative effects, it showed promising
antinociceptive and anti-inflammatory activities. The results of this study indicate
that the OEFLM has analgesic and anti-inflammatory activities in animal models by inhibiting
acute and chronic inflammation. | pt_BR |
| Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil. | pt_BR |
| Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil. | pt_BR |
| Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil. | pt_BR |
| Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil. | pt_BR |
| Affilliation | Federal University of Pernambuco. Laboratory of Pharmacotoxicological Prospecting of Bioactive Products. Department of Antibiotics. Recife, PE, Brazil. | pt_BR |
| Affilliation | State University of Ceará. Center of Education, Sciences and Technology of the Inhamuns Region. Laboratory of Bioprospecting of Natural Products and Biotechnology. Tauá, CE, Brazil. | pt_BR |
| Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil. | pt_BR |
| Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil. | pt_BR |
| Affilliation | Center for Biological and Health Sciences. Department of Biological Sciences. Crato, CE, Brazil. | pt_BR |
| Affilliation | Regional University of Cariri. Laboratory of Prospecting of Natural Products, Department of Biological Chemistry. Crato, CE, Brazil. | pt_BR |
| Affilliation | Federal University of Piauí. Center for Natural Sciences. Laboratory of Organic Geochemistry. Teresina, PI, Brazil. | pt_BR |
| Affilliation | Regional University of Cariri. , Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology. Crato, CE, Brazil. | pt_BR |
| Affilliation | University of Naples Federico II. Department of Agricultural Sciences. Portici, Italy. | pt_BR |
| Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil. | pt_BR |
| Subject | Essential oil · | pt_BR |
| Subject | Lantana montevidensis · | pt_BR |
| Subject | Anti-inflammatory activity · | pt_BR |
| Subject | Antinociceptive activity | pt_BR |
| e-ISSN | 10.1007/s10668-021-01281-8 | |
