Author | Silva, Thais Lemos | |
Author | Telleria, Erich Loza | |
Author | Traub-Csekö, Yara Maria | |
Access date | 2021-03-16T19:23:14Z | |
Available date | 2021-03-16T19:23:14Z | |
Document date | 2021 | |
Citation | SILVA, Thais Lemos; TELERIA, Erich Loza; TRAUB-CSEKO¨, Yara Maria. The gene expression of Leishmania infantum chagasi inside Lutzomyia longipalpis, the main vector of visceral leishmaniasis in Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e200571, 7p, 2021. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/46371 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Ambiente intestinal de mosca areia | pt_BR |
Subject in Portuguese | Adaptação de parasitas ao vetor | pt_BR |
Subject in Portuguese | Interação de moscas de leishmania-areia | pt_BR |
Title | The gene expression of Leishmania infantum chagasi inside Lutzomyia longipalpis, the main vector of visceral leishmaniasis in Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/0074-02760200571 | |
Abstract | Leishmania infantum chagasi is the causative agent and Lutzomyia longipalpis is the main vector of visceral leishmaniasis in
the Americas. We investigated the expression of Leishmania genes within L. longipalpis after artificial infection. mRNAs from
genes involved in sugar and amino acid metabolism were upregulated at times of high parasite proliferation inside the insect.
mRNAs from genes involved in metacyclogenesis had higher expression in late stages of infection. Other modulated genes of
interest were involved in immunomodulation, purine salvage pathway and protein recycling. These data reveal aspects of the
adaptation of the parasite to the microenvironment of the vector gut and reflect the preparation for infection in the vertebrate. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil / Charles University, Faculty of Science, Department of Parasitology. Prague, Czech Republic. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Leishmania-sand fly interaction | pt_BR |
Subject | Parasite adaptation to vector | pt_BR |
Subject | Sand fly gut environment | pt_BR |
e-ISSN | 1678-8060 | |