Author | Simões, Letícia O. | |
Author | Alves, Quiara L. | |
Author | Camargo, Samuel B. | |
Author | Araújo, Fênix A. | |
Author | Hora, Viviane R.S. | |
Author | Jesus, Rafael L.C. | |
Author | Barreto, Breno C. | |
Author | Macambira, Simone G. | |
Author | Soares, Milena Botelho Pereira | |
Author | Meira, Cássio S. | |
Author | Aguiar, Márcio C. | |
Author | Couto, Ricardo. D. | |
Author | Lomonte, Bruno | |
Author | Menezes Filho, José Evaldo | |
Author | Cruz, Jader S. | |
Author | Santos, Marcos A. Vannier | |
Author | Silva, Luciana L. Casais e | |
Author | Silva, Darizy F. | |
Access date | 2021-03-16T12:38:21Z | |
Available date | 2021-03-16T12:38:21Z | |
Document date | 2021 | |
Citation | SIMÕES, Letícia O. et al. Cardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of action. Toxicology Letters, v. 337, p. 121–133, 2021. | pt_BR |
ISSN | 0378-4274 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/46367 | |
Sponsorship | Bahia State Research Support
Foundation [FAPESB grant number 5198/2014], National Council
for Scientific and Technological Development (CNPq) and Coordination
for the Improvement of Higher Education Personnel
(CAPES) - Finance Code 001. JSC, DFS, MBPS and MAVS are CNPq
Research Fellows. | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Crotalus | pt_BR |
Subject in Portuguese | Cardiotoxicidade | pt_BR |
Subject in Portuguese | Proliferação de células | pt_BR |
Subject in Portuguese | Mitocôndrias | pt_BR |
Title | Cardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of action | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.toxlet.2020.11.019 | |
Abstract | Envenoming, resulting from snake bites, is a global public health problem. The present study was
undertaken to investigate the influence of Crotalus durissus cascavella (Cdcas) venom on cardiac activity
and the mechanisms of action underlying its effect. To investigate the inotropic and chronotropic effects
induced by Cdcas, studies were performed on the left and right atria. A series of tests were conducted to
investigate whether the negative inotropic effect, induced by Cdcas, was related to cardiac damage. Cdcas
venom (0.1 30 mg/mL) elicited a significant negative inotropic effect. The addition of Cdcas crude venom
(7.5, 15 and 30 mg/mL) did not induce significant alterations in cell proliferation, nor in the enzymatic
activity of total-CK and CK MB. Ultrastructural evaluation demonstrated that cardiac cells from
isoproterenol and Cdcas groups revealed discreet swelling and displaced intermyofibrillar mitochondria | pt_BR |
Affilliation | "Múltipla ver em Notas" | pt_BR |
Subject | Crotalus durissus cascavella | pt_BR |
Subject | Cardiotoxicity | pt_BR |
Subject | Atrial | pt_BR |