Author | Costa, Jonas Henrique | |
Author | Bazioli, Jaqueline Moraes | |
Author | Barbosa, Luidy Darllan | |
Author | Santos Júnior, Pedro Luis Theodoro dos | |
Author | Reis, Flavia Coelho Garcia dos | |
Author | Klimeck, Tabata | |
Author | Crnkovic, Camila Manoel | |
Author | Berlinck, Roberto G. S. | |
Author | Sussulini, Alessandra | |
Author | Rodrigues, Marcio Lourenço | |
Author | Fill, Taícia Pacheco | |
Access date | 2021-03-15T16:48:54Z | |
Available date | 2021-03-15T16:48:54Z | |
Document date | 2021 | |
Citation | COSTA, Jonas Henrique et al. Phytotoxic tryptoquialanines produced in vivo by Penicillium digitatum are exported in extracellular vesicles. mBio, v.12, n.1, p. 1-16, 2021. | pt_BR |
ISSN | 2150-7511 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/46363 | |
Language | por | pt_BR |
Publisher | American Society for Microbiology | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Penicillium digitatum | pt_BR |
Subject in Portuguese | Tryptoquialanine | pt_BR |
Title | Phytotoxic tryptoquialanines produced in vivo by Penicillium digitatum are exported in extracellular vesicles | pt_BR |
Type | Article | pt_BR |
DOI | https://doi.org/10.1128/mBio.03393-20 | |
Abstract | Penicillium digitatum is the most aggressive pathogen of citrus fruits. Tryptoquialanines are major indole alkaloids produced by P. digitatum. It is unknown if tryptoquialanines are involved in the damage of citrus fruits caused by P. digitatum. To investigate the pathogenic roles of tryptoquialanines, we initially asked if Tryptoquialanines could affect the germination of Citrus sinensis seeds. Exposure of the citrus seeds to tryptoquialanine A resulted in a complete inhibition of germination and an altered metabolic response. Since this phytotoxic effect requires the extracellular export of tryptoquialanine A, we investigated the mechanisms of extracellular delivery of this alkaloid in P. digitatum. We detected extracellular vesicles (EVs) released by P. digitatum both in culture and during infection of citrus fruits. Compositional analysis of EVs produced during
infection revealed the presence of a complex cargo, which included tryptoquialanines and the mycotoxin fungisporin. The EVs also presented phytotoxicity activity in vitro and caused damage to the tissues of citrus seeds. Through molecular networking, it was observed that the metabolites present in the P. digitatum EVs are produced in all of its possible hosts. Our results reveal a novel phytopathogenic role of P. digitatum EVs and tryptoquialanine A, implying that this alkaloid is exported in EVs during plant infection. | pt_BR |
Affilliation | Universidade de Campinas. Instituto de Química. Campinas, SP, Brasil. | pt_BR |
Affilliation | Universidade de Campinas. Instituto de Química. Campinas, SP, Brasil. / Universidade de Campinas. Faculdade de Ciências Farmacêuticas. Campinas, SP, Brasil. | pt_BR |
Affilliation | Universidade de Campinas. Instituto de Química. Campinas, SP, Brasil. | pt_BR |
Affilliation | Universidade de Campinas. Instituto de Química. Campinas, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Tecnologia Bioquímico-Farmacêutica. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Instituto de Química de São Carlos. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade de Campinas. Instituto de Química. Campinas, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo Góes. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade de Campinas. Instituto de Química. Campinas, SP, Brasil. | pt_BR |
Subject | Fungi | pt_BR |
Subject | Extracellular Vesicles | pt_BR |
Subject | Herbicides | pt_BR |
Subject | Host-Pathogen Interactions | pt_BR |
Subject in Spanish | Hongos | pt_BR |
Subject in Spanish | Vesículas Extracelulares | pt_BR |
Subject in Spanish | Interacciones Huésped-Patógeno | pt_BR |
Subject in French | Champignons | pt_BR |
Subject in French | Vésicules extracellulaires | pt_BR |
Subject in French | Interactions hôte-pathogène | pt_BR |
DeCS | Fungos | pt_BR |
DeCS | Vesículas Extracelulares | pt_BR |
DeCS | Herbicidas | pt_BR |
DeCS | Interações Hospedeiro-Patógeno | pt_BR |
DeCS | Penicillium | pt_BR |