Author | Safe, Izabella P. | |
Author | Amaral, Eduardo P. | |
Author | Pereira, Mariana Araújo | |
Author | Lacerda, Marcus V. G. | |
Author | Printes, Vitoria S. | |
Author | Souza, Alexandra B. | |
Author | Magalhães, Francisco Beraldi | |
Author | Monteiro, Wuelton M. | |
Author | Sampaio, Vanderson S. | |
Author | Duarte, Beatriz Barreto | |
Author | Andrade, Alice M. S. | |
Author | Gomes, Renata Spener | |
Author | Costa, Allyson Guimarães | |
Author | Santos, Marcelo Cordeiro | |
Author | Andrade, Bruno de Bezerril | |
Access date | 2021-03-15T13:54:34Z | |
Available date | 2021-03-15T13:54:34Z | |
Document date | 2021 | |
Citation | SAFE, Izabella P. et al. Adjunct N-Acetylcysteine Treatment in Hospitalized Patients With HIVAssociated Tuberculosis Dampens the Oxidative Stress in Peripheral Blood: Results From the RIPENACTB Study Trial. Frontiers in Immunology, 2021. | pt_BR |
ISSN | 1664-3224 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/46360 | |
Sponsorship | Cooperação Interfederativa do
Amazonas (Interfam), funded by the Brazilian Ministry of
Health. The study was partially supported by the Intramural
Research Program of the Fundação Oswaldo Cruz, Brazil. The
work of BA was supported by the National Institutes of Health
[grant numbers: U01AI115940, U01AI069923]. ML, WM, and
BA are senior fellows from the Conselho Nacional de
Desenvolvimento Cientı́fico e Tecnológico (CNPq), Brazil. EA
is a Research Fellow from the National Institute of Allergy and
Infectious Diseases, National Institutes of Health. MA-P received
a fellowship from Coordenação de Aperfeiçoamento de Pessoal
de Nı́vel Superior, Brazil [Finance code: 001]. | pt_BR |
Language | eng | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Tuberculose | pt_BR |
Subject in Portuguese | Estresse oxidativo | pt_BR |
Subject in Portuguese | Tratamento | pt_BR |
Subject in Portuguese | Glutationa | pt_BR |
Subject in Portuguese | Acetilcisteína | pt_BR |
Title | Adjunct N-Acetylcysteine Treatment in Hospitalized Patients With HIVAssociated Tuberculosis Dampens the Oxidative Stress in Peripheral Blood: Results From the RIPENACTB Study Trial | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fimmu.2020.602589 | |
Abstract | Tuberculosis (TB) still causes significant morbidity and mortality worldwide, especially in
persons living with human immunodeficiency virus (HIV). This disease is hallmarked by
persistent oxidative stress and systemic inflammation. N-acetylcysteine (NAC), a
glutathione (GSH) precursor, has been shown in experimental models to limit
Mycobacterium tuberculosis infection and disease both by suppression of the host
oxidative response and through direct antimicrobial activity. In a recent phase II
randomized clinical trial (RIPENACTB study), use of NAC as adjunct therapy during the
first two months of anti-TB treatment was safe. Whether adjunct NAC therapy of patients
with TB-HIV coinfection in the context of anti-TB treatment could directly affect prooxidation
and systemic inflammation has not been yet formally demonstrated. To test this
hypothesis, we leveraged existing data and biospecimens from the RIPENACTB trial to
measure a number of surrogate markers of oxidative stress and of immune activation in
peripheral blood of the participants at pre-treatment and at the day 60 of anti-TB
treatment. Upon initiation of therapy, we found that the group of patients undertaking
NAC exhibited significant increase in GSH levels and in total antioxidant status while
displaying substantial reduction in lipid peroxidation compared to the control group. Only small changes in plasma concentrations of cytokines were noted. Pharmacological
improvement of the host antioxidant status appears to be a reasonable strategy to
reduce TB-associated immunopathology. | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. | pt_BR |
Affilliation | National Institutes of Health. National Institutes of Allergy and Infectious Diseases. Immunobiology Section. Bethesda, MD, United States. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, BA, Brasil / Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, BA, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil / Universidade Federal do Amazonas. Curso de Medicina. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil / Universidade Nilton Lins. Curso de Medicina. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, BA, Brasil / Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências Curso de Medicina. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Curso de Medicina. Salvador,BA, Brasil. | pt_BR |
Subject | Tuberculosis | pt_BR |
Subject | Oxidative stress | pt_BR |
Subject | N-acetylcysteine treatment | pt_BR |
Subject | Glutathione | pt_BR |
Subject | RIPENACTB | pt_BR |