Author | Aggio, Juliana Bernardi | |
Author | Krmeska, Veronika | |
Author | Ferguson, Brian J. | |
Author | Wowk, Pryscilla Fanini | |
Author | Rothfuchs, Antonio Gigliotti | |
Access date | 2021-03-12T18:49:54Z | |
Available date | 2021-03-12T18:49:54Z | |
Document date | 2021 | |
Citation | AGGIO, Juliana Bernardi et al. Vaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node. The Journal of Immunology, p. 776-784, 2021. | pt_BR |
ISSN | 1550-6606 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/46354 | |
Language | por | pt_BR |
Publisher | The American Association of Immunologists | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Bacillus Calmette-Guérin | pt_BR |
Subject in Portuguese | BCG | pt_BR |
Title | Vaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node | pt_BR |
Type | Article | pt_BR |
DOI | https://doi.org/10.4049/jimmunol.2000928 | |
Abstract | There is a paucity of information on dendritic cell (DC) responses to vaccinia virus (VACV), including the traffic of DCs to the draining lymph node (dLN). In this study, using a mouse model of infection, we studied skin DC migration in response to VACV and compared it with the tuberculosis vaccine Mycobacterium bovis bacille Calmette–Gue´rin (BCG), another live attenuated vaccine administered via the skin. In stark contrast to BCG, skin DCs did not relocate to the dLN in response to VACV. Infection with UV-inactivated VACV or modified VACVAnkara promoted DC movement to the dLN, indicating that interference with skin DC migration requires replication-competent VACV. This suppressive effect of VACV was capable of mitigating responses to a secondary challenge with BCG in the skin, ablating DC migration, reducing BCG transport, and delaying CD4+ T cell priming in the dLN. Expression of inflammatory mediators associated with BCG-triggered DC migration were absent from virus-injected skin, suggesting that other pathways invoke DC movement in response to replication-deficient VACV. Despite adamant suppression of DC migration, VACV was still detected early in the dLN and primed Ag-specific CD4+ T cells. In summary, VACV blocks skin DC mobilization from the site of infection while retaining the ability to access the dLN to prime CD4+ T cells. | pt_BR |
Affilliation | Karolinska Institutet. Department of Microbiology, Tumor and Cell Biology. Stockholm, Sweden. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Karolinska Institutet. Department of Microbiology, Tumor and Cell Biology. Stockholm, Sweden. | pt_BR |
Affilliation | Department of Pathology. University of Cambridge. Cambridge, United Kingdom. | pt_BR |
Affilliation | Karolinska Institutet. Department of Microbiology, Tumor and Cell Biology. Stockholm, Sweden. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Karolinska Institutet. Department of Microbiology, Tumor and Cell Biology. Stockholm, Sweden. | pt_BR |
Subject | Vaccinia virus | pt_BR |
Subject | Dendritic Cells | pt_BR |
Subject | Lymph Nodes | pt_BR |
Subject | CD4-Positive T-Lymphocytes | pt_BR |
Subject in Spanish | Virus Vaccinia | pt_BR |
Subject in Spanish | Células Dendríticas | pt_BR |
Subject in Spanish | Ganglios Linfáticos | pt_BR |
Subject in Spanish | Linfocitos T CD4-Positivos | pt_BR |
Subject in French | Virus de la vaccine | pt_BR |
Subject in French | Cellules dendritiques | pt_BR |
Subject in French | Noeuds lymphatiques | pt_BR |
Subject in French | Lymphocytes T CD4+ | pt_BR |
DeCS | Vírus Vaccinia | pt_BR |
DeCS | Células Dendríticas | pt_BR |
DeCS | Mycobacterium bovis | pt_BR |
DeCS | Linfonodos | pt_BR |
DeCS | Linfócitos T CD4-Positivos | pt_BR |