Author | Silva, Valdenizia Rodrigues | |
Author | Neves, Sara Parente | |
Author | Santos, Luciano de S. | |
Author | Dias, Rosane Borges | |
Author | Bezerra, Daniel Pereira | |
Access date | 2021-02-16T12:50:37Z | |
Available date | 2021-02-16T12:50:37Z | |
Document date | 2020 | |
Citation | SILVA, Valdenizia Rodrigues et al. Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy. Cancers, v. 12, p. 1-36, 2020. | pt_BR |
ISSN | 2072-6694 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/46084 | |
Sponsorship | Coordenação de Aperfeiçoamento
de Pessoal de Nível Superior (grant number 001, CAPES, Brazil), and D.P.B. receives a personal scholarship from
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil). | pt_BR |
Language | eng | pt_BR |
Publisher | MDPI | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | autofagiaA | pt_BR |
Subject in Portuguese | Câncer | pt_BR |
Subject in Portuguese | Morte celular | pt_BR |
Subject in Portuguese | Resistência a droga | pt_BR |
Title | Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy | pt_BR |
Type | Article | pt_BR |
DOI | 10.3390/cancers12113461 | |
Abstract | Autophagy is a physiological cellular process that is crucial for development and can occurs
in response to nutrient deprivation or metabolic disorders. Interestingly, autophagy plays a dual
role in cancer cells—while in some situations, it has a cytoprotective e ect that causes chemotherapy
resistance, in others, it has a cytotoxic e ect in which some compounds induce autophagy-mediated
cell death. In this review, we summarize strategies aimed at autophagy for the treatment of cancer,
including studies of drugs that can modulate autophagy-mediated resistance, and/or drugs that cause
autophagy-mediated cancer cell death. In addition, the role of autophagy in the biology of cancer
stem cells has also been discussed. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil. | pt_BR |
Subject | Autophagy | pt_BR |
Subject | Cancer | pt_BR |
Subject | Cell death | pt_BR |
Subject | Drug resistance | pt_BR |