Author | Macedo, Débora Familiar | |
Author | Paiva, Iury Amancio | |
Author | Silva, Jessica Badolato Corrêa da | |
Author | Carvalho, Fabiana Rabe de | |
Author | Dias, Helver Gonçalves | |
Author | Corrêa, Alex Pauvolid | |
Author | Santos, Caroline Fernandes dos | |
Author | Gandini, Mariana | |
Author | Silva, Andréa Alice | |
Author | Cavalcanti, Silvia Maria Baeta | |
Author | Oliveira, Solange Artimos de | |
Author | Vianna, Renata Artimos de Oliveira | |
Author | Azeredo, Elzinandes Leal de | |
Author | Grifoni, Alba | |
Author | Sette, Alessandro | |
Author | Weiskopf, Daniela | |
Author | Cardoso, Claudete Aparecida Araújo | |
Author | Pinto, Luzia Maria de Oliveira | |
Access date | 2021-02-12T20:01:09Z | |
Available date | 2021-02-12T20:01:09Z | |
Document date | 2021 | |
Citation | MACEDO, Débora Familiar et al. Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy. Viruses, v. 12, n. 191, p. 1-18, Jan. 2021. | pt_BR |
ISSN | 1999-4915 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/46076 | |
Language | eng | pt_BR |
Publisher | MDPI | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Zika virus | pt_BR |
Subject in Portuguese | Gravidez | pt_BR |
Subject in Portuguese | Células T | pt_BR |
Subject in Portuguese | Resposta inflamatória | pt_BR |
Subject in Portuguese | Atividade citotóxica | pt_BR |
Subject in Portuguese | Receptores de quimiocina | pt_BR |
Title | Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy | pt_BR |
Type | Article | pt_BR |
DOI | 10.3390/v13020191 | |
Abstract | There have been reports of neurological abnormalities associated with the Zika virus (ZIKV),
such as congenital Zika syndrome (CZS) in children born to mothers infected during pregnancy. We
investigated how the immune response to ZIKV during pregnancy is primed and conduct a thorough
evaluation of the inflammatory and cytotoxic profiles as well as the expression of CCR5 and CX3CR1.
We compared the reactivity of T cells to ZIKV peptides in convalescent mothers infected during
pregnancy. The child’s clinical outcome (i.e., born with or without CZS) was taken to be the variable.
The cells were stimulated in vitro with ZIKV peptides and evaluated using the ELISPOT and flow
cytometry assays. After in vitro stimulation with ZIKV peptides, we observed a tendency toward
a higher Interferon gamma (IFN-
)-producing T cell responses in mothers who had asymptomatic
children and a higher CD107a expression in T cells in mothers who had children with CZS.We found
a higher frequency of T cells expressing CD107a+ and co-expressing CX3CR1+CCR5+, which is much
clearer in the T cells of mothers who had CZS children. We suggest that this differential profile
influenced the clinical outcome of babies. These data need to be further investigated, including the
evaluation of other ZIKV peptides and markers and functional assays. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Escolal de Medicina. Laboratório Multiusuário para Pesquisa em Nefrologia e Ciência Médica. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Department of Veterinary Integrative Biosciences. Texas A&M University, Texas, TX, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Laboratório Nacional de Referência e Regional Laboratório de Referência nas Américas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Escolal de Medicina. Laboratório Multiusuário para Pesquisa em Nefrologia e Ciência Médica. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Laboratório de Diagnóstico Virológico. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Escola de Medicina. Departamento Materno-Infantil. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Escola de Medicina. Departamento Materno-Infantil. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Center for Infectious Disease and Vaccine Research. La Jolla Institute for Immunology. La Jolla, CA, USA. | pt_BR |
Affilliation | Center for Infectious Disease and Vaccine Research. La Jolla Institute for Immunology. La Jolla, CA, USA / Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California. CA, USA. | pt_BR |
Affilliation | Center for Infectious Disease and Vaccine Research. La Jolla Institute for Immunology. La Jolla, CA, USA. | pt_BR |
Affilliation | Universidade Federal Fluminense. Escolal de Medicina. Laboratório Multiusuário para Pesquisa em Nefrologia e Ciência Médica. Niterói, RJ, Brasil / Universidade Federal Fluminense. Escola de Medicina. Departamento Materno-Infantil. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | ZIKV | pt_BR |
Subject | Pregnancy | pt_BR |
Subject | T cells | pt_BR |
Subject | Inflammatory response | pt_BR |
Subject | Cytotoxic activity | pt_BR |
Subject | Chemokine receptors | pt_BR |