Author | Normando, Paula | |
Author | Rebouças, Cíntia Santos | |
Author | Leung, Cindy | |
Author | Epel, Elissa | |
Author | Fonseca, Ana Carolina da | |
Author | Zembrzuski, Verônica | |
Author | Faerstein, Eduardo | |
Author | Bezerra, Flávia F. | |
Access date | 2021-02-01T18:56:27Z | |
Available date | 2021-02-01T18:56:27Z | |
Document date | 2020 | |
Citation | NORMANDO, Paula et al. Variants in gene encoding for vitamin D binding protein were associated with leukocyte telomere length: The Pr o-Sa ude Study. Nutrition, v. 71, 110618, 6p, 2020. | pt_BR |
ISSN | 0899-9007 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/45903 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Telômero | pt_BR |
Subject in Portuguese | Envelhecimento | pt_BR |
Subject in Portuguese | Vitamina D | pt_BR |
Subject in Portuguese | Polimorfismos de nucleotídeos únicos | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Title | Variants in gene encoding for vitamin D binding protein were associated with leukocyte telomere length: The Pr o-Sa ude Study | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.nut.2019.110618 | |
Abstract | Objective: The aim of this study was to investigate the association between single-nucleotide polymorphisms
(SNPs) in vitamin D metabolic pathway genes, serum 25-hydroxyvitamin D [25(OH)D] concentrations, and
leukocyte telomere length (LTL) in Brazilian adults.
Methods: The study population comprised 461 participants (33 79 y of age; 51% women) from the Pr o-Sa ude
Study, a cohort of civil servants at a university campus in Rio de Janeiro, Brazil. LTL, genotypes of vitamin Drelated
SNPs (rs12785878, rs10741657, rs6013897, and rs2282679), and serum 25(OH)D concentrations were
determined cross-sectionally. Differences in age- and sex-adjusted LTL means by categories of genotypes and 25
(OH)D serum concentrations were evaluated. LTL associations with genotypes and 25(OH)D were investigated
using multiple linear regression models adjusted for sociodemographic characteristics and markers of health
behavior.
Results: Participants with CC genotype (rs2282679) had shorter age- and sex-adjusted mean LTL than those with
AC and AA genotypes (mean § SE: 0.51 § 0.03, 0.58 § 0.01 and 0.5 § 0.01, respectively, P < 0.05). In adjusted
analyses, the CC genotype (rs2282679) was inversely associated with LTL (b = 0.061; 95% confidence interval,
0.120 to 0.001). Other vitamin D-related SNPs and serum 25(OH)D concentrations were not associated
with LTL.
Conclusions: Genetic variations in the gene encoding vitamin D binding protein (GC - rs2282679) were associated
with LTL, suggesting an influence of vitamin D status on telomere length that may start early in life. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro, Instituto de Nutrição. Rio de Janiero, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcantara Gomes. Rio de Janiero, RJ, Brasil. | pt_BR |
Affilliation | University of California San Francisco. San Francisco, California, USA / School of Public Health University of Michigan. Michigan, USA> | pt_BR |
Affilliation | University of California San Francisco. San Francisco, California, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Medicina Social. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro, Instituto de Nutrição. Rio de Janiero, RJ, Brasil. | pt_BR |
Subject | Telomere | pt_BR |
Subject | Aging | pt_BR |
Subject | Vitamin D | pt_BR |
Subject | SNP | pt_BR |
Subject | Brazil | pt_BR |