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HUMAN BOCAVIRUS IN BRAZIL: MOLECULAR EPIDEMIOLOGY, VIRAL LOAD AND CO-INFECTIONS
Bocavírus humano
Co-infecções
Carga viral
Genotipagem
Brasil
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Escola de Medicina. Departamento de Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil.
Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia.. Niterói, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Escola de Medicina. Departamento de Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.
Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia.. Niterói, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Escola de Medicina. Departamento de Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.
Abstract
Human bocavirus (HBoV) is an emerging virus and has been detected worldwide, especially
in pediatric patients with respiratory and gastrointestinal infection. In this study, we describe HBoV
prevalence, genotypes circulation andDNAshedding, in stool samples fromchildren up to two years of
age in Brazil. During 2016 and 2017, 886 acute gastroenteritis (AGE) stool samples from ten Brazilian
states were analyzed by TaqMan®-based qPCR, to detect and quantify HBoV. Positive samples
were genotyped by sequencing the VP1/2 overlap region, followed by phylogenetic analysis and
co-infections were accessed by screening other gastroenteric viruses. HBoV was detected in 12.4%
(n = 110) of samples, with viral load ranging from 1.6 102 to 1.2 109 genome copies per gram of
stool. From these, co-infections were found in 79.1%, and a statistically lower HBoV viral load was
found compared to viral loads of rotavirus, norovirus and adenovirus in double infected patients
(p < 0.05). No significant di erences were found between HBoV viral load in single or co-infections,
age groups or genotypes. Phylogenetic analysis identified the circulation of HBoV-1 in 38%, HBoV-2
in 40% and HBoV-3 in 22%. Continuous HBoV monitoring is needed to clarify its role in diarrhea
disease, especially in the absence of classic gastroenteric viruses.
Keywords in Portuguese
Gastroenterite agudaBocavírus humano
Co-infecções
Carga viral
Genotipagem
Brasil
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