Author | Soares, Isabel Ferreira | |
Author | Camacho, César López | |
Author | Silva, Rodrigo Nunes Rodrigues da | |
Author | Matos, Ada da Silva | |
Author | Baptista, Barbara de Oliveira | |
Author | Totino, Paulo Renato Rivas | |
Author | Souza, Rodrigo Medeiros de | |
Author | Harrison, Kate | |
Author | Gimenez, Alba Marina | |
Author | Freitas, Elisângela Oliveira de | |
Author | Kim, Young Chan | |
Author | Ferreira, Joseli Oliveira | |
Author | Daniel‑Ribeiro, Cláudio Tadeu | |
Author | Reyes‑Sandova, Arturo | |
Author | Pratt‑Riccio, Lilian Rose | |
Author | Lima Junior, Josué da Costa | |
Access date | 2021-01-11T19:20:45Z | |
Available date | 2021-01-11T19:20:45Z | |
Document date | 2020 | |
Citation | SOARES, Isabel Ferreira et al. Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon. Scientifc Reports, v. 10, 14020, 14p, 2020. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/45648 | |
Language | eng | pt_BR |
Publisher | Nature Research | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Plasmodium Recombinante | pt_BR |
Subject in Portuguese | Superfície circunsporozoíta vivax | pt_BR |
Subject in Portuguese | Proteína alélica | pt_BR |
Subject in Portuguese | Anticorpo | pt_BR |
Subject in Portuguese | Amazônia brasileira | pt_BR |
Title | Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon | pt_BR |
Type | Article | pt_BR |
DOI | /10.1038/s41598-020-70893-3 | |
Abstract | Circumsporozoite protein (CSP) variants of P. vivax, besides having variations in the protein
repetitive portion, can differ from each other in aspects such as geographical distribution, intensity
of transmission, vectorial competence and immune response. Such aspects must be considered to
P. vivax vaccine development. Therefore, we evaluated the immunogenicity of novel recombinant
proteins corresponding to each of the three P. vivax allelic variants (VK210, VK247 and P. vivax-like)
and of the C-terminal region (shared by all PvCSP variants) in naturally malaria-exposed populations
of Brazilian Amazon. Our results demonstrated that PvCSP-VK210 was the major target of humoral
immune response in studied population, presenting higher frequency and magnitude of IgG response.
The IgG subclass profile showed a prevalence of cytophilic antibodies (IgG1 and IgG3), that seem to
have an essential role in protective immune response. Differently of PvCSP allelic variants, antibodies
elicited against C-terminal region of protein did not correlate with epidemiological parameters,
bringing additional evidence that humoral response against this protein region is not essential to
protective immunity. Taken together, these findings increase the knowledge on serological response
to distinct PvCSP allelic variants and may contribute to the development of a global and effective P.
vivax vaccine. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology. University of Oxford, Oxford, UK. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia de Imunobiológicos. Laboratório de Tecnologia em Anticorpos Monoclonais. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Acre. Centro de Pesquisa em Doenças Infecciosas. Centro Multidisciplinar, Campus Floresta. Rio Branco, AC, Brasil. | pt_BR |
Affilliation | Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology. University of Oxford, Oxford, UK. | pt_BR |
Affilliation | Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology. University of Oxford, Oxford, UK. | pt_BR |
Affilliation | Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology. University of Oxford, Oxford, UK. | pt_BR |
Affilliation | Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology. University of Oxford, Oxford, UK. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Centro de Pesquisa, Diagnóstico e Tratamento em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology. University of Oxford, Oxford, UK. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Recombinant Plasmodium | pt_BR |
Subject | Vivax circumsporozoite surface | pt_BR |
Subject | Protein allelic | pt_BR |
Subject | Antibody | pt_BR |
Subject | Brazilian Amazon | pt_BR |
e-ISSN | 2045-2322 | |