Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/45539
EXTRACELLULAR VESICLES IN VIRAL INFECTIONS: TWO SIDES OF THE SAME COIN?
Extracellular Vesicles
Host-Pathogen Interactions
Virion
Active Immune Response
Vesículas Extracelulares
Interacciones Huésped-Patógeno
Virión
Inmunidad Activa
Vesículas Extracelulares
Interações Hospedeiro-Patógeno
Vírion
Imunidade Ativa
Affilliation
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil. / Universidade Federal do Paraná. Setor de Ciências Biológicas. Curitiba. PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil.
Abstract
Extracellular vesicles are small membrane structures containing proteins and nucleic acids that are gaining a lot of attention lately. They are produced by most cells and can be detected in several body fluids, having a huge potential in therapeutic and diagnostic approaches. EVs produced by infected cells usually have a molecular signature that is very distinct from healthy cells. For intracellular pathogens like viruses, EVs can have an even more complex function, since the viral biogenesis pathway can overlap with EV pathways
in several ways, generating a continuum of particles, like naked virions, EVs containing infective viral genomes and quasi-enveloped viruses, besides the classical complete viral particles that are secreted to the extracellular space. Those particles can act in recipient cells in different ways. Besides being directly infective, they also can prime neighbor cells rendering them more susceptible to infection, block antiviral responses and deliver
isolated viral molecules. On the other hand, they can trigger antiviral responses and cytokine secretion even in uninfected cells near the infection site, helping to fight the infection and protect other cells from the virus. This protective response can also backfire, when a massive inflammation facilitated by those EVs can be responsible for bad clinical outcomes. EVs can help or harm the antiviral response, and sometimes both mechanisms are observed in infections by the same virus. Since those pathways are intrinsically interlinked, understand the role of EVs during viral infections is crucial to comprehend viral mechanisms and respond better to emerging viral diseases.
Keywords
Virus InfectionsExtracellular Vesicles
Host-Pathogen Interactions
Virion
Active Immune Response
Keywords in Spanish
VirosisVesículas Extracelulares
Interacciones Huésped-Patógeno
Virión
Inmunidad Activa
DeCS
Infecções por VírusVesículas Extracelulares
Interações Hospedeiro-Patógeno
Vírion
Imunidade Ativa
Share