Author | Oliveira, Luiz Antonio Pimentel Lopes | |
Author | Fantinatti, Maria | |
Author | Cruz, Alda Maria da | |
Access date | 2020-11-24T15:38:53Z | |
Available date | 2020-11-24T15:38:53Z | |
Document date | 2020 | |
Citation | OLIVEIRA, Luiz Antonio Pimentel Lopes; FANTINATTI, Maria; CRUZ, Alda Maria da. In vitro-induction of metronidazole-resistant Giardia duodenalis is not associated with nucleotide alterations in the genes involved in pro-drug activation. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 115, e200303, 4p, 2020. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/44606 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Giardia duodenalis | pt_BR |
Subject in Portuguese | Metronidazol | pt_BR |
Subject in Portuguese | Resistência | pt_BR |
Title | In vitro-induction of metronidazole-resistant Giardia duodenalis is not associated with nucleotide alterations in the genes involved in pro-drug activation | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/0074-02760200303 | |
Abstract | Giardiasis is an infectious disease caused by Giardia duodenalis. The pro-drug metronidazole (MTZ) is the first-line treatment
for giardiasis. Parasite’s proteins as pyruvate:ferredoxin oxidoreductase (PFOR), ferredoxin (Fd), nitroreductase-1 (NR-1) and
thioredoxin reductase (TrxR) participate in MTZ activation. Here, we showed Giardia trophozoites long-term exposed to MTZ
presented higher IC50 than controls, showing the drug influenced the parasite survival. That reduction in MTZ’s susceptibility
does not seem to be related to mutations in the genes pfor, fd, nr-1 or trxr. It points that different mechanism as alterations in other
metabolic pathways can account for Giardia resistance to MTZ therapy. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Disciplina de Parasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Giardia duodenalis | pt_BR |
Subject | Metronidazole | pt_BR |
Subject | Resistance | pt_BR |
e-ISSN | 1678-8060 | |