Author | Vieira, Thiago de Souza | |
Author | Iniguez, Eva | |
Author | Castro, Waldione de | |
Author | Karmakar, Subir | |
Author | Disotuar, Maria M. | |
Author | Cecilio, Pedro | |
Author | Lacsina, Joshua R. | |
Author | Meneses, Claudio | |
Author | Nagata, Bianca M. | |
Author | Cardoso, Silvia | |
Author | Sonenshine, Daniel E. | |
Author | Moore, Ian N. | |
Author | Borges, Valeria de Matos | |
Author | Dey, Ranadhir | |
Author | Soares, Miguel P. | |
Author | Nakhasi, Hira L. | |
Author | Oliveira, Fabiano | |
Author | Valenzuela, Jesus G. | |
Author | Kamhawi, Shaden | |
Access date | 2020-11-23T14:15:33Z | |
Available date | 2020-11-23T14:15:33Z | |
Document date | 2020 | |
Citation | VIEIRA, Thiago de Souza et al. Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance. Cell Reports, p. 1-18, Oct. 27 2020. | pt_BR |
ISSN | 2211-1247 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/44586 | |
Sponsorship | We thank Ana Beatriz F. Barletta (LMVR, National Institute of Allergy and Infectious
Diseases [NIAID]), Owen M. Schwartz, and Margery Smelkinson (Biological
Imaging Facility, Research Technology Branch, NIAID) for their support
with the confocal microscope and Lucas Tirloni (LMVR, NIAID) for his insights
into tick biology. The graphical abstract is courtesy of Visual Medical Arts,
NIAID, Rocky Mountain Labs; the illustration is by Ryan Kissinger. This
research was supported by the Intramural Research Program of the NIH,
NIAID. The findings of this study are an informal communication and represent | pt_BR |
Language | eng | pt_BR |
Publisher | Cell Press | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Heme oxigenase | pt_BR |
Subject in Portuguese | Inflamação | pt_BR |
Subject in Portuguese | Pele | pt_BR |
Subject in Portuguese | Leishmania | pt_BR |
Title | Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.celrep.2020.108317 | |
Abstract | Hematophagous vectors lacerate host skin and capillaries to acquire a blood meal, resulting in leakage of red blood cells (RBCs) and inflammation. Here, we show that heme oxygenase-1 (HO-1), a pleiotropic cytoprotective isoenzyme that mitigates heme-mediated tissue damage, is induced after bites of sand flies, mosquitoes, and ticks. Further, we demonstrate that erythrophagocytosis by macrophages, including a skinresiding CD163+CD91+ professional iron-recycling subpopulation, produces HO-1 after bites. Importantly, we establish that global deletion or transient inhibition of HO-1 in mice increases inflammation and pathology following Leishmania-infected sand fly bites without affecting parasite number, whereas CO, an end product of the HO-1 enzymatic reaction, suppresses skin inflammation. This indicates that HO-1 induction by bloodfeeding sand flies promotes tolerance to Leishmania infection. Collectively, our data demonstrate that HO-1 induction through erythrophagocytosis is a universal mechanism that regulates skin inflammation following blood feeding by arthropods, thus promoting early-stage disease tolerance to vector-borne pathogens. | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA. | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA. | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA. | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA. | pt_BR |
Affilliation | Center for Biologics Evaluation and Research. Food and Drug Administration. Laboratory of Emerging Pathogens. Division of Emerging and Transfusion Transmitted Diseases. Silver Spring, MD, USA | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA. | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA. | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA. | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA. | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Infectious Disease Pathogenesis Section, Comparative Medicine Branch. Rockville, MD, USA. | pt_BR |
Affilliation | Instituto Gulbenkian de Ciência. Oeiras, Lisboa, Portugal. | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA. | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Infectious Disease Pathogenesis Section. Comparative Medicine Branch. Rockville, MD, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Center for Biologics Evaluation and Research. Food and Drug Administration. Laboratory of Emerging Pathogens. Division of Emerging and Transfusion Transmitted Diseases. Silver Spring, MD, USA | pt_BR |
Affilliation | Instituto Gulbenkian de Ciência. Oeiras, Lisboa, Portugal. | pt_BR |
Affilliation | Center for Biologics Evaluation and Research. Food and Drug Administration. Laboratory of Emerging Pathogens. Division of Emerging and Transfusion Transmitted Diseases. Silver Spring, MD, USA | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA. | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA. | pt_BR |
Subject | Heme oxigenaes | pt_BR |
Subject | Inflammation | pt_BR |
Subject | Skin | pt_BR |
Subject | Leishmania | pt_BR |