Author | Araújo, Thádia Evelyn de | |
Author | Santos, Luara Isabela dos | |
Author | Gomes, Angelica Oliveira | |
Author | Carneiro, Ana Carolina Aguiar Vasconcelos | |
Author | Machado, Anderson Silva | |
Author | Reis, Jordana Grazziela Coelho Dos | |
Author | Pascoal, Vanessa Peruhype Magalhães | |
Author | Béla, Samantha Ribeiro | |
Author | Andrade, Gláucia Manzan Queiroz | |
Author | Santos, Daniel Vitor Vasconcelos | |
Author | Januário, José Nélio | |
Author | Carvalho, Andréa Teixeira de | |
Author | Vitor, Ricardo Wagner Almeida | |
Author | Antonelli, Lis Ribeiro do Valle | |
Author | Ferro, Eloisa Amália Vieira | |
Author | Martins Filho, Olindo Assis | |
Access date | 2020-10-29T16:58:13Z | |
Available date | 2020-10-29T16:58:13Z | |
Document date | 2020 | |
Citation | DE ARAUJO, Thadia Evelyn et al. Putative biomarkers for early diagnosis and prognosis of congenital ocular toxoplasmosis. Sci Rep, v. 10, n. 1, 16757, 2020. https://doi.org/10.1038/s41598-020-73265-z | pt_BR |
ISSN | 2045-2322 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/44259 | |
Language | eng | pt_BR |
Publisher | Nature | pt_BR |
Rights | open access | pt_BR |
Title | Putative biomarkers for early diagnosis and prognosis of congenital ocular toxoplasmosis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1038/s41598-020-73265-z. | |
Abstract | In the present study we have evaluated the performance of several immunological biomarkers for early diagnosis and prognosis of congenital toxoplasmosis. Our results showed that ex vivo serum levels of CXCL9, and the frequencies of circulating CD4+CD25+ T-cells and T. gondii-specific IFN-γ+CD4+ T-cells measured 30-45 days after birth presented high accuracy to distinguish T. gondii-infected infants from healthy age-matched controls (Global Accuracy/AUC = 0.9; 0.9 and 0.8, respectively). Of note was the enhanced performance (Accuracy = 96%) achieved by using a combined stepwise analysis of CD4+CD25+ T-cells and CXCL9. In addition, high global accuracy (AUC = 0.9) with elevated sensitivity (Se = 98%) was also reached by using the total frequency of in vitro IFN-γ-producing T. gondii-specific T-cells (∑ IFN-γ+ CD4+ & CD8+) as a biomarker of congenital toxoplasmosis. Furthermore, the analysis of in vitro T. gondii-specific IL5+CD4+ T-cells and IFN-γ+NK-cells displayed a high accuracy for early prognosis of ocular lesion in infant with congenital toxoplasmosis (Global Accuracy/AUC = 0.8 and 0.9, respectively). Together, these findings support the relevance of employing the elements of the cell-mediated immune response as biomarkers with potential to endorse early diagnosis and prognosis of congenital ocular toxoplasmosis to contribute for a precise clinical management and effective therapeutic intervention. | pt_BR |
Affilliation | Universidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Uberlândia, MG, Brazil./Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Faculdade de Ciências Médicas de Minas Gerais. Belo Horizonte, MG, Brazil/Faculdade de Ciências Médicas de Minas Gerais. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Pediatria. Belo Horizonte, MG, Brazil./Universidade Federal de Minas Gerais. Núcleo de Ações e Pesquisa em Apoio Diagnóstico. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Núcleo de Ações e Pesquisa em Apoio Diagnóstico. Belo Horizonte, MG, Brazil./Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Oftalmologia e Otorrinolaringologia. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Núcleo de Ações e Pesquisa em Apoio Diagnóstico. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Uberlândia, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Uberlândia, MG, Brazil. | pt_BR |
Subject | Diagnostic markers | pt_BR |
Subject | Prognostic markers | pt_BR |
Subject | Cytokines | pt_BR |
Subject | Immunology | pt_BR |
Subject | Infectious diseases | pt_BR |
Subject | Parasitic infection | pt_BR |