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DETECTION OF CIRCULANT TUMOR NECROSIS FACTOR-A, SOLUBLE TUMOR NECROSIS FACTOR P75 AND INTERFERON-G IN BRAZILIAN PATIENTS WITH DENGUE FEVER AND DENGUE HEMORRHAGIC FEVER
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.
Universidade de Pernambuco.Instituto de Ciências Biológicas. Departamento de Patologia. Recife, PE, Brasil.
Laboratório Central. Departamento de Virologia,. Recife, PE, Brasil.
Laboratório Central. Departamento de Virologia,. Recife, PE, Brasil.
Laboratório Central. Departamento de Virologia,. Recife, PE, Brasil.
Laboratório Central. Departamento de Virologia,. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.
Universidade de Pernambuco.Instituto de Ciências Biológicas. Departamento de Patologia. Recife, PE, Brasil.
Laboratório Central. Departamento de Virologia,. Recife, PE, Brasil.
Laboratório Central. Departamento de Virologia,. Recife, PE, Brasil.
Laboratório Central. Departamento de Virologia,. Recife, PE, Brasil.
Laboratório Central. Departamento de Virologia,. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.
Abstract
Pro-inflammatory cytokines are believed to play an important role in the pathogenesis of dengue
infection. This study reports cytokine levels in a total of 54 patients examined in Recife, State of
Pernambuco, Brazil. Five out of eight patients who had hemorrhagic manifestations presented tumor
necrosis factor-α (TNF-α) levels in sera which were statistically higher than those recorded for controls. In contrast, only one out of 16 patients with mild manifestations had elevated TNF-α levels. The
levels of interleukin-6 (IL), IL-1β tested in 24 samples and IL-12 in 30 samples were not significantly
increased. Interferon-γ was present in 10 out of 30 patients with dengue. The data support the concept
that the increased level of TNF-α is related to the severity of the disease. Soluble TNF receptor p75 was
found in most patients but it is unlikely to be related to severity since it was found with an equivalent
frequency and levels in 15 patients with dengue fever and another 15 with dengue hemorrhagic fever.
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