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https://www.arca.fiocruz.br/handle/icict/43525
CHRONIC HEPATITIS B INFECTION IS ASSOCIATED WITH INCREASED MOLECULAR DEGREE OF INFLAMMATORY PERTURBATION IN PERIPHERAL BLOOD
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Centro Universitário Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil.
Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Faculdade de Medicina, Universidade Federal da Bahia, Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multination/ al Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Faculdade de Medicina, Universidade Federal da Bahia, Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Centro Universitário Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Medicina, Universidade Federal da Bahia, Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Centro Universitário Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Faculdade de Medicina, Universidade Federal da Bahia, Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Faculdade de Medicina, Universidade Federal da Bahia, Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multination/ al Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Faculdade de Medicina, Universidade Federal da Bahia, Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Centro Universitário Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Medicina, Universidade Federal da Bahia, Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Centro Universitário Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Faculdade de Medicina, Universidade Federal da Bahia, Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Abstract
Hepatitis B virus (HBV) infection remains a major public health concern. The interaction
between HBV and the host inflammatory response is an important contributing factor driving liver
damage and diseases outcomes. Here, we performed a retrospective analysis employing an adapted
molecular degree of perturbation (MDP) score system to assess the overall inflammatory imbalance
related to persistent HBV infection. Plasma levels of several cytokines, chemokines, and other
inflammatory markers were measured in Brazilian individuals diagnosed with either chronic HBV or
previous HBV infection, as well as in uninfected controls between 2006 and 2007. Multidimensional
analyses were used to depict and compare the overall expression profile of inflammatory markers
between distinct clinical groups. Chronic HBV patients exhibited a marked inflammatory imbalance,
characterized by heightened MDP scores and a distinct profile of correlation networks inputting
plasma concentrations of the biomarkers, compared with either individuals with previous HBV or
controls. Furthermore, in participants with chronic HBV infection, the viral loads in peripheral blood
were directly proportional to overall molecular perturbation as well as to specific perturbations of
interleukin (IL)-4 and interferon (IFN)-
concentrations. These findings highlight additional nuances
about systemic inflammation related to persistent HBV infection.
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