Author | Amorim, Cláudia Zuany | |
Author | Marques, Arthur Diaz | |
Author | Cordeiro, Renato Sergio Balão | |
Access date | 2020-09-18T20:19:19Z | |
Available date | 2020-09-18T20:19:19Z | |
Document date | 1991 | |
Citation | AMORIM, Cláudia Zuany; MARQUES, Arthur Diaz; CORDEIRO, Renato Sergio Balão. Screening of the antimalarial activity of plants of the Cucurbitaceae family. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 86, Suppl. 2, p. 177-180, 1991. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/43468 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Plasmodium berghei | pt_BR |
Subject in Portuguese | Cucurbitaceae | pt_BR |
Subject in Portuguese | Momordica charantia | pt_BR |
Subject in Portuguese | Plasmodium berghei | pt_BR |
Subject in Portuguese | Rastreio de drogas | pt_BR |
Subject in Portuguese | Extratos vegetais | pt_BR |
Subject in Portuguese | Antimaláricos | pt_BR |
Subject in Portuguese | Terapia medicamentosa | pt_BR |
Title | Screening of the antimalarial activity of plants of the Cucurbitaceae family | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/S0074-02761991000600040 | |
Abstract | Crude ethanolic extracts (CEEs) from two species of Cucurbitaceae, Cucurbita maxima and Momordica charantia (commonly called "abóbora moranga" and melão de São Caetano", respectively) were assayed for antimalarial activity by the 4-d suppressive test. The CEE of dry C. maxima seeds showed strong antimalarial activity following oral administration (259 and 500 mg/kg), reducing by 50% the levels of parasistemia in Plasmodium berghey-infected mice. Treatment of normal animals with 500 mg/Kg of the extract three days before intravenous injection of P. berghei caused a significant 30% reduction in parasitemic levels. No effect was observed when the animals were treated with the CEE only on the day of inoculation. Oral administration of the CEE of dry M. charantia leaves adminstered orally was ineffective up to 500 mg/Kg in lowering the parasitemic levels of malarious mice. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Antimalarials | pt_BR |
Subject | Drug therapy | pt_BR |
Subject | Natural products | pt_BR |
Subject | Plant extracts | pt_BR |
Subject | Drug screening | pt_BR |
Subject | Plasmodium berghei | pt_BR |
Subject | Curcubita maxima | pt_BR |
Subject | Momordica charantia | pt_BR |
Subject | Cucurbitaceae | pt_BR |
e-ISSN | 1678-8060 | |