Author | Lopes, Denielle de Souza | |
Author | Santos, Uener Ribeiro dos | |
Author | Anjos, Danielle Oliveira dos | |
Author | Silva Júnior, Lauro José Caires da | |
Author | Paula, Vanderlúcia Fonseca de | |
Author | Santos, Marcos André Vannier | |
Author | Jardim, Izaltina Silva | |
Author | Gomes, Thiago Castro | |
Author | Pirovani, Carlos Priminho | |
Author | Santos, Jane Lima | |
Access date | 2020-08-04T17:43:21Z | |
Available date | 2020-08-04T17:43:21Z | |
Document date | 2020 | |
Citation | LOPES, Danielle de Sousa et al. Ethanolic Extract of the Fungus Trichoderma asperelloides Induces Ultrastructural Effects and Death on Leishmania amazonensis. Front. Cell. Infect. Microbiol, v. 10. Article 306, July 2020. | pt_BR |
ISSN | 2235-2988 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/42531 | |
Language | eng | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmania amazonensis | pt_BR |
Subject in Portuguese | Leishmaniose | pt_BR |
Subject in Portuguese | Quimioterapia | pt_BR |
Subject in Portuguese | Trichoderma | pt_BR |
Subject in Portuguese | Leishmanicida | pt_BR |
Subject in Portuguese | Leishmania amazonensis | pt_BR |
Title | Ethanolic Extract of the Fungus Trichoderma asperelloides Induces Ultrastructural Effects and Death on Leishmania amazonensis | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fcimb.2020.00306 | |
Abstract | The Trichoderma genus comprises several species of fungi whose diversity of secondary
metabolites represents a source of potential molecules with medical application. Because
of increased pathogen resistance and demand for lower production costs, the search for
new pharmacologically active molecules effective against pathogens has become more
intense. This is particularly evident in the case of American cutaneous leishmaniasis due
to the high toxicity of current treatments, parenteral administration, and increasing rate
of refractory cases. We have previously shown that a fungus from genus Trichoderma
can be used for treating cerebral malaria in mouse models and inhibit biofilm formation.
Here, we evaluated the effect of the ethanolic extract of Trichoderma asperelloides
(Ext-Ta) and its fractions on promastigotes and amastigotes of Leishmania amazonensis,
a major causative agent of cutaneous leishmaniasis in the New World. Ext-Ta displayed
leishmanicidal action on L. amazonensis parasites, and its pharmacological activity
was associated with the low-molecular-weight fraction (LMWF) of Ext-Ta. Ultrastructural
analysis demonstrated morphological alterations in the mitochondria and the flagellar
pocket of promastigotes, with increased lipid body and acidocalcisome formation,
microtubule disorganization of the cytoplasm, and intense vacuolization of the cytoplasm
when amastigotes were present. We suggest the antiparasitic activity of Trichoderma
fungi as a promising tool for developing chemotherapeutic leishmanicidal agents. | pt_BR |
Affilliation | Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, Brasil. | pt_BR |
Affilliation | Universidade Estadual Do Sudoeste da Bahia. Laboratório de Produtos Naturais. Jequié, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Laboratório de Biologia Celular e Parasitos Intracelulares. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, Brasil. | pt_BR |
Subject | Trichoderma | pt_BR |
Subject | Chemotherapy | pt_BR |
Subject | Leishmanicidal | pt_BR |
Subject | Leishmaniasis | pt_BR |
Subject | Leishmania amazonensis | pt_BR |