Author | Cruz, Luan Firmino | |
Author | Ricardo, Debora Decote | |
Author | Gomes, Daniel Claudio de Oliveira | |
Author | Morrot, Alexandre | |
Author | Lima, Celio Geraldo Freire de | |
Author | Guedes, Herbert Leonel de Matos | |
Access date | 2020-08-03T20:10:07Z | |
Available date | 2020-08-03T20:10:07Z | |
Document date | 2020 | |
Citation | CRUZ, Luan Firmino et al. How to B(e)-1 important cell during Leishmania infection. Frontiers in Cellular and Infection Microbiology, v. 9, Article 424, p. 1-8, Jan. 2020. | pt_BR |
ISSN | 2235-2988 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/42517 | |
Language | eng | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmaniose | pt_BR |
Subject in Portuguese | BALB/XID | pt_BR |
Subject in Portuguese | Células B-1CDP | pt_BR |
Subject in Portuguese | IL-10 | pt_BR |
Title | How to B(e)-1 important cell during Leishmania infection | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fcimb.2019.00424 | |
Abstract | B-1 cells are an innate-like population of B lymphocytes that are subdivided into B-1a
and B-1b distinguished by the presence or absence of CD5, respectively. B-1 cells can
act as regulatory B cells, are able to present antigen and produce IL-10. Leishmaniasis
in humans is a complex of diseases caused by parasites of the genus Leishmania.
More than 20 species can infect humans, with each species causing the development
of different immunological responses in the host. Susceptibility is usually related to
the production of anti-inflammatory cytokines while the production of Th1 cytokines is
indicative of resistance. However, few studies have attempted to evaluate the role of B-1
cells during either the in vivo infection or in vitro interaction with Leishmania parasites.
In vivo studies were performed using XID mice model, BALB/Xid mice have a mutation
in the Bruton’s tyrosine kinase, which is an important enzyme for developing B-1 and
maturing B-2 lymphocytes leading to the presence of immature B-2 cells. Here, we
compile these studies and assess the influence of B-1 cells on disease progression with
different Leishmania species. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Espírito Santo. Núcleo de Doenças Infecciosas / Núcleo de Biotecnologia. Vitória, ES, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil./ Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Imunomodulação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Núcleo Multidisciplinar de Pesquisa UFRJ—Xerém em Biologia (NUMPEX-BIO). J Campus Duque de Caxias Professor Geraldo Cidade. Duque de Caxias, RJ, Brasil. | pt_BR |
Subject | Leishmaniasis | pt_BR |
Subject | BALB/XID | pt_BR |
Subject | B-1 cells | pt_BR |
Subject | B-1CDP cells | pt_BR |
Subject | IL-10 | pt_BR |