Author | Bianchi, Martina | |
Author | Benvenuto, Domenico | |
Author | Giovanetti, Marta | |
Author | Angeletti, Silvia | |
Author | Ciccozzi, Massimo | |
Author | Pascarella, Stefano | |
Access date | 2020-07-27T20:51:10Z | |
Available date | 2020-07-27T20:51:10Z | |
Document date | 2020 | |
Citation | BIANCHI, Martina et al. Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics? Biomed Research International, v. 2020, Article ID 4389089, p. 1-6, 2020. | pt_BR |
ISSN | 2314-6133 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/42416 | |
Language | eng | pt_BR |
Publisher | Hindawi Publishing Corporation | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | SARS-CoV-2 | pt_BR |
Subject in Portuguese | Envelope SARS-CoV-2 | pt_BR |
Subject in Portuguese | Proteínas de membrana | pt_BR |
Subject in Portuguese | Estruturais Diferenças | pt_BR |
Subject in Portuguese | Características do vírus | pt_BR |
Subject in Portuguese | COVID-19 | pt_BR |
Title | Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics? | pt_BR |
Type | Article | pt_BR |
DOI | 10.1155/2020/4389089 | |
Abstract | The Coronavirus Disease 2019 (COVID-19) is a new viral infection caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2). Genomic analyses have revealed that SARS-CoV-2 is related to Pangolin and Bat coronaviruses. In this report, a structural comparison between the Sars-CoV-2 Envelope and Membrane proteins from different human isolates with homologous proteins from closely related viruses is described. The analyses here reported show the high structural similarity of Envelope and Membrane proteins to the counterparts from Pangolin and Bat coronavirus isolates. However, the comparisons have also highlighted structural differences specific of Sars-CoV-2 proteins which may be correlated to the cross-species transmission and/or to the properties of the virus. Structural modelling has been applied to map the variant sites onto the predicted three-dimensional structure of the Envelope and Membrane proteins. | pt_BR |
Affilliation | Sapienza University of Rome. Department of Biochemical sciences “A Rossi Fanelli”. Rome, Italy. | pt_BR |
Affilliation | University Campus Bio-Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | University Campus Bio-Medico of Rome. Unit of Clinical Laboratory Science. Rome, Italy. | pt_BR |
Affilliation | University Campus Bio-Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy. | pt_BR |
Affilliation | Sapienza University of Rome. Department of Biochemical sciences “A Rossi Fanelli”. Rome, Italy. | pt_BR |
Subject | SARS-CoV-2 | pt_BR |
Subject | Envelope and Membrane proteins | pt_BR |
Subject | Structural Differences | pt_BR |
Subject | Virus Characteristics | pt_BR |
Subject | COVID-19 | pt_BR |
e-ISSN | 2314-6141 | |