Author | Martins, Anita Oliveira Brito Pereira Bezerra | |
Author | Wanderley, Almir Gonçalves | |
Author | Alcântara, Isabel Sousa | |
Author | Rodrigues, Lindaiane Bezerra | |
Author | Cesário, Francisco Rafael Alves Santana | |
Author | Oliveira, Maria Rayane Correia de | |
Author | Castro, Fyama Ferreira E | |
Author | Albuquerque, Thaís Rodrigues de | |
Author | Silva, Maria Sanadia Alexandre da | |
Author | Ribeiro Filho, Jaime | |
Author | Coutinho, Henrique Douglas Melo | |
Author | Menezes, Paula Passos | |
Author | Quintans Júnior, Lucindo José | |
Author | Araújo, Adriano Antunes de Souza | |
Author | Iriti, Marcello | |
Author | Almeida, Jackson Roberto Guedes da Silva | |
Author | Menezes, Irwin Rose Alencar de | |
Access date | 2020-07-21T12:19:52Z | |
Available date | 2020-07-21T12:19:52Z | |
Document date | 2020 | |
Citation | MARTINS, Anita Oliveira Brito Pereira Bezerra et al. Anti-Inflammatory and Physicochemical Characterization of the Croton Rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin. Biology, v. 9, 2020. | pt_BR |
ISSN | s/id | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/42318 | |
Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil
(CAPES—Finance Code 001), CNPq, FACEPE, FINEP and FUNCAP. | pt_BR |
Language | eng | pt_BR |
Publisher | MDPI | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Croton rhamnifolioides | pt_BR |
Subject in Portuguese | Ciclodextrina | pt_BR |
Subject in Portuguese | Inflamação | pt_BR |
Title | Anti-Inflammatory and Physicochemical Characterization of the Croton Rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin | pt_BR |
Type | Article | pt_BR |
DOI | 10.3390/biology9060114 | |
Abstract | Croton rhamnifolioides is used in popular medicine for the treatment of inflammatory diseases. The objective of this study was to characterize and evaluate the anti-inflammatory effect of C. rhamnifolioides essential oil complexed in β-cyclodextrin (COEFC). The physicochemical characterization of the complexes was performed using different physical methods. The anti-inflammatory activity was evaluated in vivo by ear edema, paw edema, cotton pellet-induced granuloma, and vascular permeability by Evans blue extravasation. The mechanism of action was validated by molecular docking of the major constituent into the cyclooxygenase-2 (COX-2 enzyme). All doses of the COEFC reduced acute paw edema induced by carrageenan and dextran, as well as vascular permeability. Our results suggest the lowest effective dose of all samples inhibited the response induced by histamine or arachidonic acid as well as the granuloma formation. The complexation process showed that the pharmacological effects were maintained, however, showing similar results using much lower doses. The results demonstrated an involvement of the inhibition of pathways dependent on eicosanoids and histamine. Complexation of β-cyclodextrin/Essential oil (β-CD/EO) may present an important tool in the study of new compounds for the development of anti-inflammatory drugs. | pt_BR |
Affilliation | Federal University of Pernambuco. Laboratory of Pharmacology and Preclinical Bioactive Product Toxicology. Recife, PE, Brazil. | pt_BR |
Affilliation | Federal University of Pernambuco. Laboratory of Pharmacology and Preclinical Bioactive Product Toxicology. Recife, PE, Brazil. | pt_BR |
Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry, Pimenta, Crato, CE, Brazil. | pt_BR |
Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry, Pimenta, Crato, CE, Brazil. | pt_BR |
Affilliation | Federal University of Ceara. Laboratory of Pharmacology and Molecular Chemistry. Department of Physiology and Pharmacology. Fortaleza, CE, Brazil. | pt_BR |
Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry, Pimenta, Crato, CE, Brazil. | pt_BR |
Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry, Pimenta, Crato, CE, Brazil. | pt_BR |
Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry, Pimenta, Crato, CE, Brazil. | pt_BR |
Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry, Pimenta, Crato, CE, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | University of Cariri. Laboratory of Microbiology and Molecular Biology. Department of Biological Chemistry. Crato, CE, Brazil. | pt_BR |
Affilliation | Federal University of Sergipe. Laboratory of Pharmaceutical Testing and Toxicity. Department of Pharmacy. São Cristóvão, SE, Brazil. | pt_BR |
Affilliation | Federal University of Sergipe. Laboratory of Neuroscience and Pharmacological Assays. Department of Physiology. São Cristóvão, SE, Brazil. | pt_BR |
Affilliation | Federal University of Sergipe. Laboratory of Neuroscience and Pharmacological Assays. Department of Physiology. São Cristóvão, SE, Brazil. | pt_BR |
Affilliation | Milan State University. Department of Agricultural and Environmental Sciences. Milan, Italy. | pt_BR |
Affilliation | Federal University of Vale Sao Francisco. Laboratory of Pharmacology. Department of Pharmacy. Petrolina, PE, Brazil. | pt_BR |
Affilliation | Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry, Pimenta, Crato, CE, Brazil. | pt_BR |
Subject | Croton rhamnifolioides | pt_BR |
Subject | Cyclodextrin | pt_BR |
Subject | Inflammation | pt_BR |