Author | Lourenco, Mychael V. | |
Author | Frozza, Rudimar L. | |
Author | Freitas, Guilherme B. de | |
Author | Zhang, Hong | |
Author | Kincheski, Grasielle C. | |
Author | Ribeiro, Felipe C. | |
Author | Gonçalves, Rafaella A. | |
Author | Clarke, Julia R. | |
Author | Beckman, Danielle | |
Author | Staniszewski, Agnieszka | |
Author | Berman, Hanna | |
Author | Guerra, Lorena A. | |
Author | Forny-Germano, Letícia | |
Author | Meier, Shelby | |
Author | Wilcock, Donna M. | |
Author | Souza, Jorge M. de | |
Author | Alves-Leon, Soniza | |
Author | Prado, Vania F. | |
Author | Prado, Marco A. M. | |
Author | Abisambra, Jose F. | |
Author | Tovar-Moll, Fernanda | |
Author | Mattos, Paulo | |
Author | Arancio, Ottavio | |
Author | Ferreira, Sergio T. | |
Author | De Felice, Fernanda G. | |
Access date | 2020-06-15T19:36:38Z | |
Available date | 2020-06-15T19:36:38Z | |
Document date | 2019 | |
Citation | LOURENCO, Mychael V. et al. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Nature Medicine, v. 25, p. 165-175, Jan. 2019. | pt_BR |
ISSN | 1078-8956 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/41658 | |
Description | O artigo encontra-se disponível em acesso aberto no site da Editora. | pt_BR |
Language | eng | pt_BR |
Publisher | Nature Research | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Resgates FNDC5 | pt_BR |
Subject in Portuguese | Irisina | pt_BR |
Subject in Portuguese | Plasticidade sináptic | pt_BR |
Subject in Portuguese | Defeitos de memóri | pt_BR |
Subject in Portuguese | Modelos de Alzheimer | pt_BR |
Title | Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models | pt_BR |
Type | Article | pt_BR |
DOI | 10.1038/s41591-018-0275-4 | |
Abstract | Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released on cleavage of the membrane-bound precursor protein fibronectin type III domain-containing protein 5 (FNDC5), also expressed in the hippocampus. Here we show that FNDC5/irisin levels are reduced in AD hippocampi and cerebrospinal fluid, and in experimental AD models. Knockdown of brain FNDC5/irisin impairs long-term potentiation and novel object recognition memory in mice. Conversely, boosting brain levels of FNDC5/irisin rescues synaptic plasticity and memory in AD mouse models. Peripheral overexpression of FNDC5/irisin rescues memory impairment, whereas blockade of either peripheral or brain FNDC5/irisin attenuates the neuroprotective actions of physical exercise on synaptic plasticity and memory in AD mice. By showing that FNDC5/irisin is an important mediator of the beneficial effects of exercise in AD models, our findings place FNDC5/irisin as a novel agent capable of opposing synapse failure and memory impairment in AD. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Taub Institute for Research on Alzheimer’s Disease and the Aging Brain. Columbia University. New York, NY, USA. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Centre for Neuroscience Studies. Queen’s University. Kingston, Ontario, Canada. | pt_BR |
Affilliation | Taub Institute for Research on Alzheimer’s Disease and the Aging Brain.Columbia University. New York, NY, USA. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Centre for Neuroscience Studies. Queen’s University. Kingston, Ontario, Canada. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Escola de Farmácia. Rio de Janeiro, RJ, Brasil. . | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Taub Institute for Research on Alzheimer’s Disease and the Aging Brain. Columbia University. New York, NY, USA.. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Sanders-Brown Center on Aging. University of Kentucky. Lexington, KY, USA. | pt_BR |
Affilliation | Sanders-Brown Center on Aging. University of Kentucky. Lexington, KY, USA. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Neurocirurgia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Neurologia/Programa de Epilepsia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Robarts Research Institute. University of Western Ontario. London, Ontario, Canada / Department of Physiology and Pharmacology. University of Western Ontario. London, Ontario, Canada / Department of Anatomy & Cell Biology. University of Western Ontario, London, Ontario, Canada. | pt_BR |
Affilliation | Robarts Research Institute. University of Western Ontario. London, Ontario, Canada / Department of Physiology and Pharmacology. University of Western Ontario. London, Ontario, Canada / Department of Anatomy & Cell Biology. University of Western Ontario, London, Ontario, Canada. | pt_BR |
Affilliation | Sanders-Brown Center on Aging. University of Kentucky. Lexington, KY, USA. | pt_BR |
Affilliation | Instituto D´Or para Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto D´Or para Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Psiquiatria. Rio de Janeiro, RJ, Brasil.. | pt_BR |
Affilliation | Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA / Universidade Federal do Rio de Janeiro. Escola de Farmácia. Rio de janeiro, RJ, Brasil / Columbia University. Department of Medicine. New York, NY, USA | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Centre for Neuroscience Studies. Queen’s University. Kingston, Ontario, Canada / Department of Psychiatry, Queen’s University. Kingston, Ontario, Canada. | pt_BR |
Subject | Alzheimer’s models | pt_BR |
Subject | Synaptic plasticity | pt_BR |
Subject | Memory defects | pt_BR |
Subject | Irisin rescues | pt_BR |
Subject | Exercise-linked FNDC5 | pt_BR |
e-ISSN | 1546-170X | |
Embargo date | 2022-01-01 | |