Author | Santos, Isis Fernandes Magalhães | |
Author | Lemaire, Denise Carneiro | |
Author | Andrade Filho, Antonio de Souza | |
Author | Queiroz, Aristides Cheto de | |
Author | Carvalho, Otavio Augusto Moreno | |
Author | Carmo, Theomira Mauadie de Azevedo | |
Author | Siqueira, Isadora Cristina de | |
Author | Andrade, Débora M | |
Author | Rego, Michely F | |
Author | Guedes, Ana Paula Torres | |
Author | Reis, Mitermayer Galvão dos | |
Access date | 2012-07-13T19:44:56Z | |
Available date | 2012-07-13T19:44:56Z | |
Document date | 2003 | |
Citation | MAGALHÃES-SANTOS, I.F. et al. Antibodies to Schistosoma mansoni in human cerebrospinal fluid. American Journal of Tropical Medicine and Hygiene, v. 68, n. 3, p. 294-8, mar. 2003. | pt_BR |
ISSN | 0002-9637 | |
URI | https://www.arca.fiocruz.br/handle/icict/4162 | |
Language | eng | pt_BR |
Rights | open access | |
Title | Antibodies to Schistosoma mansoni in human cerebrospinal fluid | pt_BR |
Type | Article | pt_BR |
Defense date | 2003 | |
Departament | Centro de Pesquisas Gonçalo Moniz | pt_BR |
Defense Institution | Fundação Oswaldo Cruz | pt_BR |
Place of Defense | Salvador | pt_BR |
Abstract | Cerebrospinal fluid (CSF) and serum samples from patients suspected of having neuroschistosomiasis (NS)
were evaluated by an enzyme-linked immunosorbent assay. Monoclonal antibodies of various immunoglobulin isotypes
(IgM, IgA, IgE, total IgG, IgG1, IgG2, IgG3, and IgG4) were used to detect antibodies against Schistosoma mansoni
soluble egg antigen (SEA) and soluble worm adult preparation (SWAP). Of the 83 CSF samples tested, 55% were
reactive toSEA (26% were reactive only toSEA and 29% tobo th SEA and SWAP), 34% were reactive toSWAP (5%
only to SWAP and 29% to both SEA and SWAP), and 40% were not reactive with any antigen. Cases that tested
positive for SWAP in CSF and negative in serum were not found. Samples with high specific IgG antibody titers were
selected for immunoglobulin isotype profiling. In the CSF samples, the antibodies against SEA and SWAP were mainly
IgM, IgG1, and IgG4, although other immunoglobulins were also detected. Interestingly, nine patients had high levels
of IgG1 only in the CSF. These results suggest that there is local synthesis of IgG1, and that this isotype could be an
important immunologic marker in the diagnosis of NS. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | José Silveira Foundation. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
xmlui.metadata.dc.title.original | Antibodies to Schistosoma mansoni in human cerebrospinal fluid | pt_BR |
DeCS | Anticorpos Anti-Helmínticos/líquido cefalorraquidiano | pt_BR |
DeCS | Doenças do Sistema Nervoso/líquido cefalorraquidiano | pt_BR |
DeCS | Schistosoma mansoni/imunologia | pt_BR |
DeCS | Esquistossomose/líquido cefalorraquidiano | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Idoso | pt_BR |
DeCS | Ensaio de Imunoadsorção Enzimática | pt_BR |
DeCS | Isotipos de Imunoglobulinas/imunologia | pt_BR |
DeCS | Doenças do Sistema Nervoso/parasitologia | pt_BR |
DeCS | Esquistossomose/parasitologia | pt_BR |