Author | Borges, Claudia Maria da Cunha | |
Author | Andrade, Zilton de Araújo | |
Access date | 2012-07-09T21:19:34Z | |
Available date | 2012-07-09T21:19:34Z | |
Document date | 2003 | |
Citation | BORGES, C. M.; ANDRADE, Z. A. Extra-cellular matrix changes in Schistosoma mansoni-infected Biomphalaria glabrata. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 1, p. 135-9, Jan. 2003. | pt_BR |
ISSN | 0074-0276 | |
URI | https://www.arca.fiocruz.br/handle/icict/4160 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Title | Extra-cellular matrix changes in Schistosoma mansoni-infected Biomphalaria glabrata | pt_BR |
Type | Article | pt_BR |
Defense date | 2003 | |
Defense Institution | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz | pt_BR |
Place of Defense | Salvador | pt_BR |
Abstract | Reactivity of snails against parasites exhibits a primitive focal reaction, with encapsulation, phagocytosis and destruction of parasite larvae by macrophage-like cells - the hemocytes. This reaction mimics granulomatous inflammation seen in higher animals. However, different from the latter, little is known about the participation of extra-cellular matrix in such snail defense reactions. Normal and Schistosoma mansoni-infected Biomphalaria glabrata of different strains were submitted to cytological, histological, ultrastructural and biochemical methods in order to investigate the behavior of extra-cellular tissues at the site of anti-parasite reactions. In spite of the presence of two cell-types in peripheral hemolymph, only one cell-type was present at the sites of tissue reactions. Although pre-existent collagen and elastic fibers and microfibrils sometimes appeared slightly compressed around focal reactions, no evidences of duplication, synthesis or deposition of connective-tissue extra-cellular components were observed within or around the zones of reactive cell accumulations. Thus, tissue reactions against S. mansoni in the snail B. glabrata appeared exclusively dependent on one specific population of hemocytes. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Subject | Biomphalaria glabrata | pt_BR |
Subject | Schistosoma mansoni | pt_BR |
Subject | Hemocytes | pt_BR |
Subject | Encapsulating complexes | pt_BR |
Subject | Extra-cellular matrix | pt_BR |
DeCS | Biomphalaria/parasitologia | pt_BR |
DeCS | Células do Tecido Conjuntivo/parasitologia | pt_BR |
DeCS | Matriz Extracelular/parasitologia | pt_BR |
DeCS | Hemócitos/parasitologia | pt_BR |
DeCS | Schistosoma mansoni/patogenicidade | pt_BR |