Author | Paulino, Niraldo | |
Author | Dantas, Andreia Pires | |
Author | Bankova, Vassya | |
Author | Longhi, Daniela Taggliari | |
Author | Scremin, Amarilis | |
Author | Castro, Solange Lisboa de | |
Author | Calixto, João Batista | |
Access date | 2020-05-20T15:24:24Z | |
Available date | 2020-05-20T15:24:24Z | |
Document date | 2003 | |
Citation | PAULINO, Niraldo et al. Bulgarian propolis induces analgesic and anti-inflammatory effects in mice and inhibits in vitro contraction of airway smooth muscle. Journal of Pharmacological Sciences. v. 93, p. 307-313, 2003. | pt_BR |
ISSN | 1347-8613 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/41325 | |
Language | eng | pt_BR |
Publisher | The Japanese Pharmalogical Society | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Própolis | pt_BR |
Subject in Portuguese | Agente antiinflamatório | pt_BR |
Subject in Portuguese | Efeito antiespamódico | pt_BR |
Title | Bulgarian propolis induces analgesic and anti-inflammatory effects in mice and inhibits in vitro contraction of airway smooth muscle | pt_BR |
Type | Article | pt_BR |
DOI | 10.1254/jphs.93.307 | |
Abstract | Propolis is a bee product, which has long been used in folk medicine for the management of different diseases. In this study we evaluated the analgesic and anti-inflammatory effects of a standard ethanolic extract of Bulgarian propolis (Et-Blg) in mice and its in vitro effect on airway smooth muscle. Et-Blg inhibited acetic acid-induced abdominal contortions with an ID(50) = 7.4 +/- 0.7 mg. kg(-1). In the formalin test, the extract caused a significant reduction in pain in mice treated with 100 mg. kg(-1) Et-Blg during the neurogenic phase and for the inflammatory phase with all doses of the extract, with an ID(50) = 2.5 +/- 0.4 mg. kg(-1). Et-Blg inhibited also the capsaicin-induced ear edema in mice; however, this extract was ineffective when assessed in the tail-flick and hot-plate thermal assays. The analgesic effect of Et-Blg was associated with the inhibition of inflammatory responses and not to a simple irritation of nervous terminals. In vitro, this extract inhibited the contraction of trachea smooth muscle induced by histamine (IC(50) = 50 +/- 5 microg. mL(-1)), capsaicin (IC(50) = 26.8 +/- 3 microg. mL(-1)), 80 mM KCl (IC(50) = 27.8 +/- 3 microg. mL(-1)), and carbachol (IC(50) = 54 +/- 2 microg. mL(-1)). | pt_BR |
Affilliation | Universidade do Sul de Santa Catarina. Grupo de Pesquisa e Desenvolvimento de Biofármacos. Tubarão, SC, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-Estrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Institute of Organic Chemistry with Centre of Phytochemistry. Sofia, Bulgaria. | pt_BR |
Affilliation | Universidade do Sul de Santa Catarina. Grupo de Pesquisa e Desenvolvimento de Biofármacos. Tubarão, SC, Brasil. | pt_BR |
Affilliation | Universidade do Sul de Santa Catarina. Grupo de Pesquisa e Desenvolvimento de Biofármacos. Tubarão, SC, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil. | pt_BR |
Subject | Propolis | pt_BR |
Subject | Anti-nociception agent | pt_BR |
Subject | Anti-inflammatory agent | pt_BR |
Subject | Guinea pig trachea | pt_BR |
Subject | Antispasmodic effect | pt_BR |
e-ISSN | 1347--8648 | |