Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/41132
PROTECTIVE IMMUNITY AFTER COVID-19 HAS BEEN QUESTIONED: WHAT CAN WE DO WITHOUT SARS-COV-2-IGG DETECTION?
https://www.arca.fiocruz.br/handle/icict/51490
Affilliation
Oswaldo Cruz Foundation. Immunobiological Technology Institute (Bio-Manguinhos). Laboratory of Immunological Technology. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Immunobiological Technology Institute (Bio-Manguinhos). Laboratory of Immunological Technology. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Immunobiological Technology Institute (Bio-Manguinhos). Laboratory of Immunological Technology. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Immunobiological Technology Institute (Bio-Manguinhos). Laboratory of Immunological Technology. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Immunobiological Technology Institute (Bio-Manguinhos). Laboratory of Immunological Technology. Rio de Janeiro, RJ, Brazil.
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a severe acute respiratory syndrome that is called COVID-19. Clinical manifestations of COVID-19 include diarrhea, pneumonia, lymphopenia, exhausted lymphocytes, and pro-inflammatory cytokine production. Immunology is part of the process of clinical evolution, but there are some questions around immunity-based protection: (1) why some infected people have only mild symptoms of the disease or are asymptomatic; (2) why delayed and weak antibody responses are associated with severe outcomes; and (3) why positivity in molecular tests does not represent protective antibody IgG. Perhaps T cell responses may be the key to solving those questions. SARS-CoV-2-specific memory T cells persist in peripheral blood and may be capable of providing effective information about protective immunity. The T cells studies can be helpful in elucidating the pathways for development of vaccines, therapies, and diagnostics for COVID-19 and for filling these immunology knowledge gaps.
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