Author | Araújo, Ana Carolina Justino de | |
Author | Freitas, Priscilla Ramos | |
Author | Barbosa, Cristina Rodrigues dos Santos | |
Author | Muniz, Débora F | |
Author | Esmeraldo Rocha, Janaína | |
Author | Araújo Neto, José B de | |
Author | Silva, Maria M. C da | |
Author | Moura, Talysson F | |
Author | Pereira, Raimundo L S | |
Author | Ribeiro Filho, Jaime | |
Author | Silva, Luiz E da | |
Author | Amaral, Wanderlei do | |
Author | Deschamps, Cícero | |
Author | Tintino, Saulo R | |
Author | Iriti, Marcello | |
Author | Vitalini, Sara | |
Author | Coutinho, Henrique D Melo | |
Access date | 2020-04-08T17:48:44Z | |
Available date | 2020-04-08T17:48:44Z | |
Document date | 2020 | |
Citation | ARAÚJO, Ana Carolina Justino de et al. Oil of Croton ceanothifolius Baill. Potentiates the Effect of Antibiotics against Multiresistant Bacteria. Antibiotics, v. 9, 2020. | pt_BR |
ISSN | 2079-6382 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/40689 | |
Language | eng | pt_BR |
Publisher | MDPI | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Antibióticos | pt_BR |
Subject in Portuguese | Resistência bacteriana | pt_BR |
Subject in Portuguese | Croton ceanothifolius | pt_BR |
Subject in Portuguese | Óleos essenciais | pt_BR |
Title | Essential Oil of Croton ceanothifolius Baill. Potentiates the Effect of Antibiotics against Multiresistant Bacteria | pt_BR |
Type | Article | pt_BR |
DOI | 10.3390/antibiotics9010027 | |
Abstract | This study is a pioneer in reporting the antibacterial properties of the species Croton ceanothifolius Baill. The genus Croton belongs to the family Euphorbiaceae composed of numerous species with documented biological activities. However, the pharmacological properties of C. ceanothifolius remain poorly understood. The leaves of this plant were submitted to hydrodistillation for essential oil (CcEO) extraction and the phytochemical characterization of the oil was performed by GC/MS. The minimum inhibitory concentration of the CcEO was determined for the evaluation of antibacterial activity against multiresistant strains of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. The antibiotic-modulating activity of the oil, in combination with antibiotics, was also evaluated. The combination of the CcEO with penicillin, norfloxacin, and gentamicin presented a synergistic effect. This effect was more significant for the association with antibiotics of the quinolone and aminoglycoside classes against Escherichia coli. The association of oil with gentamicin showed better results with regard to the Gram-positive strain. The association of the oil with norfloxacin against P. aeruginosa also showed synergism, but the association with penicillin did not change the effect of this antibiotic. Thus, it is concluded that C. ceanothifolius essential oil selectively potentiates the action of antibiotics against multiresistant strains. | pt_BR |
Affilliation | Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brasil. | pt_BR |
Affilliation | Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brasil. | pt_BR |
Affilliation | Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brasil. | pt_BR |
Affilliation | Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brasil. | pt_BR |
Affilliation | Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brasil. | pt_BR |
Affilliation | Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brasil. | pt_BR |
Affilliation | Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brasil. | pt_BR |
Affilliation | Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brasil. | pt_BR |
Affilliation | Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Federal University of Paraná. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Federal University of Paraná. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Federal University of Paraná. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brasil. | pt_BR |
Affilliation | Milan State University. Department of Agricultural and Environmental Sciences. Milan, Italy. | pt_BR |
Affilliation | Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brasil. | pt_BR |
Subject | Antibiotics | pt_BR |
Subject | Bacterial resistance | pt_BR |
Subject | Croton ceanothifolius | pt_BR |
Subject | Essential oils | pt_BR |