Author | Araujo, Nelia Cláudia Neri | pt_BR |
Author | Cruz, Constança Margarida Sampaio | pt_BR |
Author | Arriaga Gutiérrez, María Belen | pt_BR |
Author | Cubillos-Angulo, Juan Manuel | pt_BR |
Author | Rocha, Michael Santos | pt_BR |
Author | Mattos, Paulo Sérgio de Morais da Silveira | pt_BR |
Author | Matos, Gisela M. | pt_BR |
Author | Marques, Izabella M. B. | pt_BR |
Author | Espírito Santo, Isa Carolina Paim do | pt_BR |
Author | Almeida, Luiza L. | pt_BR |
Author | Andrade, Caroline M. | pt_BR |
Author | Souza, Leonardo A. | pt_BR |
Author | Martins Netto, Eduardo | pt_BR |
Author | Andrade, Bruno de Bezerril | pt_BR |
Access date | 2020-04-07T18:03:57Z | |
Available date | 2020-04-07T18:03:57Z | |
Document date | 2020 | |
Citation | ARAUJO, Nelia Cláudia Neri et al. Determinants losses in the latent tuberculosis cascade of care in Brazil: a retrospective cohort study. International Journal of Infectious Diseases, p. 1-23, Feb. 2020. | pt_BR |
ISSN | 1201-9712 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/40672 | |
Sponsorship | Fundação de Amparo à Pesquisa do Estado
da Bahia (FAPESB). The funders had no role in study design, data extraction and analysis, the
decision to publish, or the preparation of the manuscript. | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Tuberculose | pt_BR |
Subject in Portuguese | Infecção latente por TB | pt_BR |
Subject in Portuguese | Cscata LTBI | pt_BR |
Subject in Portuguese | Tratamento para TB latente | pt_BR |
Title | Determinants of losses in the latent tuberculosis cascade of care in Brazil: A retrospective cohort study | pt_BR |
Type | Preprint | pt_BR |
DOI | 10.1016/j.ijid.2020.02.015 | pt_BR |
Abstract | The present study evaluated factors associated with losses in the latent tuberculosis infection (LTBI) cascade of care in contacts of tuberculosis (TB) patients, in a referral center from a highly endemic region in Brazil. Methods: Contacts of 1,672 TB patients were retrospectively studied between 2009 and 2014.
Data on TB screening by clinical investigation, radiographic examination and tuberculin skin test
(TST) were extracted from medical records. Losses in the cascade of care and TB incidence
within 2-year follow-up were calculated.
Results: From a total of 1,180 TB contacts initially identified, only 495 were examined (58% loss),
and 20 were diagnosed with active TB at this stage. Furthermore, 435 persons returned for TST
result interpretation and 351 (~81%) were TST positive. Among those with positive TST, 249
(73%) were treated with isoniazid for 6 months whereas 51 abandoned therapy early. Three
individuals who did not receive LTBI treatment, one with incomplete treatment and another who
completed treatment developed active TB. A logistic regression analysis revealed that increases
in age were associated with losses in the LTBI cascade independent of other clinical and
epidemiological characteristics.
Conclusions: Major losses occur at initial stages and older patients are at higher risk of not
completing the LTBI cascade of care. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil / Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil / Obras Sociais Irmã Dulce. Salvador, BA, Brasil. | pt_BR |
Affilliation | Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil. | pt_BR |
Affilliation | Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil. | pt_BR |
Subject | Tuberculosis | pt_BR |
Subject | Latent TB infection | pt_BR |
Subject | LTBI cascade | pt_BR |
Subject | Treatment for latent TB | pt_BR |