Author | Mendes, Ana Luisa Gomes | |
Author | Joaquim, Heloísa Di Matteo | |
Author | Zamae, Mara Inês Stefanini | |
Author | Assis, Ramon Meira | |
Author | Peixoto, Jéssica Renata de Moura | |
Author | Araújo, Margarida Maria Gomes de | |
Author | Guedes, Antônio Carlos Martins | |
Author | Oliveira, Edward José | |
Author | Paschoal, Vanessa Peruhype Magalhães | |
Author | Xavier, Marcelo Antônio Pascoal | |
Access date | 2020-03-30T13:36:10Z | |
Available date | 2020-03-30T13:36:10Z | |
Document date | 2020 | |
Citation | MENDES, Ana Luisa Gomes et al. Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 115, p. 1-7, 2020. | pt_BR |
ISSN | 1678-8060 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/40553 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz | pt_BR |
Rights | open access | pt_BR |
Title | Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/0074-02760190324 | |
Abstract | BACKGROUND: Leprosy is an infectious-contagious disease caused by Mycobacterium leprae that remain endemic in 105 countries. This neglected disease has a wide range of clinical and histopathological manifestations that are related to the host inflammatory and immune responses. More recently, the inflammasome has assumed a relevant role in the inflammatory response against microbiological agents. However, the involvement of inflammasome in leprosy remains poorly understood.
OBJECTIVES: The aim is to associate biomarkers of inflammasome with the different immunopathological forms of leprosy.
METHODS: We performed an observational, cross-sectional, and comparative study of the immunophenotypic expression of inflammasome-associated proteins in immunopathological forms of leprosy of 99 skin lesion samples by immunohistochemistry. The intensity and percentage of NLRP3, Caspase-1, Caspases-4/5, interleukin-1β and interleukin-18 immunoreactivities in the inflammatory infiltrate of skin biopsies were evaluated.
FINDINGS: Strong expression of NLRP3 and inflammatory Caspases-4/5 were observed in lepromatous leprosy (lepromatous pole). In addition, were observed low expression of caspase-1, interleukin-1β, and interleukin-18 in tuberculoid and lepromatous leprosy. The interpolar or borderline form showed immunophenotype predominantly similar to the lepromatous pole.
MAIN CONCLUSIONS: Our results demonstrate that the NLRP3 inflammasome is inactive in leprosy, suggesting | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Subject | Leprosy | pt_BR |
Subject | Inflammasome | pt_BR |
Subject | NLRP3 | pt_BR |
Subject | Caspase | pt_BR |