Author | Araújo, Julianna Siciliano de | |
Author | Silva, Patrícia Bernardino da | |
Author | Batista, Marcos Meuser | |
Author | Peres, Raiza Brandão | |
Author | Santos, Camila Cardoso | |
Author | Kalejaiye, Titilola D. | |
Author | Munday, Jane C. | |
Author | De Heuvel, Erik | |
Author | Sterk, Geert Jan | |
Author | Augustyns, Koen | |
Author | Salado, Irene G. | |
Author | Matheeussen, An | |
Author | De Esch, Iwan | |
Author | De Koning, Harry P. | |
Author | Leurs, Rob | |
Author | Maes, Louis | |
Author | Soeiro, Maria de Nazaré Correia | |
Access date | 2020-03-23T20:00:15Z | |
Available date | 2020-03-23T20:00:15Z | |
Document date | 2020 | |
Citation | ARAÚJO, Julianna Siciliano de et al. Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi, J. Antimicrob. Chemother., v. 75, p. 958-967, Dec. 2019. | pt_BR |
ISSN | 0305-7453 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/40465 | |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Inibidores da ftalazinona fosfodiesterase | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Avaliação | pt_BR |
Title | Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/jac/dkz516 | |
Abstract | Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi, needs urgent alternative therapeutic options as the treatments currently available display severe limitations, mainly related to efficacy and toxicity. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | University of Glasgow. College of Medical, Veterinary & Life Sciences, Institute of Infection, Immunity & Inflammation. Glasgow, UK. | pt_BR |
Affilliation | University of Glasgow. College of Medical, Veterinary & Life Sciences, Institute of Infection, Immunity & Inflammation. Glasgow, UK. | pt_BR |
Affilliation | Vrije Universiteit Amsterdam. Amsterdam Institute for Molecules, Medicines & Systems. Medicinal Chemistry. Amsterdam, The Netherlands. | pt_BR |
Affilliation | Vrije Universiteit Amsterdam. Amsterdam Institute for Molecules, Medicines & Systems. Medicinal Chemistry. Amsterdam, The Netherlands. | pt_BR |
Affilliation | University of Antwerp. Laboratory of Medicinal Chemistry. Antwerp, Belgium. | pt_BR |
Affilliation | University of Antwerp. Laboratory of Medicinal Chemistry. Antwerp, Belgium. | pt_BR |
Affilliation | University of Antwerp. Laboratory for Microbiology, Parasitology and Hygiene. Antwerp, Belgium. | pt_BR |
Affilliation | Vrije Universiteit Amsterdam. Amsterdam Institute for Molecules, Medicines & Systems. Medicinal Chemistry. Amsterdam, The Netherlands. | pt_BR |
Affilliation | University of Glasgow. College of Medical, Veterinary & Life Sciences, Institute of Infection, Immunity & Inflammation. Glasgow, UK. | pt_BR |
Affilliation | Vrije Universiteit Amsterdam. Amsterdam Institute for Molecules, Medicines & Systems. Medicinal Chemistry. Amsterdam, The Netherlands. | pt_BR |
Affilliation | University of Antwerp. Laboratory for Microbiology, Parasitology and Hygiene. Antwerp, Belgium. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Evaluation | pt_BR |
Subject | Phthalazinone phosphodiesterase inhibitor | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
e-ISSN | 1460-2091 | |
Embargo date | 2022-01-01 | |