Author | Souza, Andréa P. de | |
Author | Oliveira, Gabriel Melo de | |
Author | Vanderpas, Jean | |
Author | Castro, Solange L. de | |
Author | Rivera, Maria Teresa | |
Author | Araujo-Jorge, Tania C. | |
Access date | 2020-03-17T14:22:28Z | |
Available date | 2020-03-17T14:22:28Z | |
Document date | 2003 | |
Citation | SOUZA, Andréa P. de et al. Selenium supplementation at low doses contributes to the decrease in heart damage in experimental Trypanosoma cruzi infection. Parsitol Res., v. 91, p. 51-54, 2003. | pt_BR |
ISSN | 0932-0113 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/40355 | |
Language | eng | pt_BR |
Publisher | Springer Verlag (Germany) | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Suplementação de selênio | pt_BR |
Subject in Portuguese | Doses baixas | pt_BR |
Subject in Portuguese | Dano cardíaco | pt_BR |
Subject in Portuguese | Infecção experimental | pt_BR |
Title | Selenium supplementation at low doses contributes to the decrease in heart damage in experimental Trypanosoma cruzi infection | pt_BR |
Type | Article | pt_BR |
DOI | 10.1007/s00436-003-0867-9 | |
Abstract | Chagasic patients with cardiomyopathy have low levels of selenium (Se), a fundamental trace element. We evaluated the effect of supplementing infected mice with Se (0.25-16 ppm). Supplementation with 0.25 or 1 ppm Se led to parasitaemia and survival curves similar to those of the control group. Mice treated with 4-16 ppm showed a dose-dependent decrease of parasitaemia, significant for the highest concentration. This was probably due to a direct effect on the parasites, which were lysed after in vitro incubation with Se. Survival rates did not change significantly; however, heart damage was reduced in infected mice supplemented with 4 ppm Se, as indicated by a lower cardiac isoform of creatine kinase levels. Our results imply that Se supplementation does not lead to a general protection during infection, but may help protect the heart from inflammatory damage. The effect of Se supplementation in the course of T. cruzi infection depends on the host-parasite pair employed. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hópital Ambroise-Paré. Mons, Belgium. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | Selenium supplementation | pt_BR |
Subject | Experimental infection | pt_BR |
Subject | Heart damage | pt_BR |
Subject | Low doses | pt_BR |
e-ISSN | 1432-1955 | |
Embargo date | 2025-01-01 | |