Author | Amaral, Ana Claudia Fernandes | |
Author | Gomes, Luciana A. | |
Author | Silva, Jefferson Rocha de Andrade | |
Author | Ferreira, José Luiz Pinto | |
Author | Ramos, Aline de Souza | |
Author | Rosa, Maria do Socorro S. | |
Author | Vermelho, Alane B. | |
Author | Rodrigues, Igor A. | |
Access date | 2020-03-02T19:35:28Z | |
Available date | 2020-03-02T19:35:28Z | |
Document date | 2014 | |
Citation | AMARAL, Ana Claudia F. et al. Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity. BioMed Research International, p. 1-9, 2014. | pt_BR |
ISSN | 2314-6141 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/40174 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Title | Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity | pt_BR |
Type | Article | pt_BR |
DOI | 10.1155/2014/694934 | pt_BR |
Abstract | Promastigote forms of Leishmania amazonensis were treated with different concentrations of two fractions of Curcuma longa cortex
rich in turmerones and their respective liposomal formulations in order to evaluate growth inhibition and the minimal inhibitory
concentration (MIC). In addition, cellular alterations of treated promastigotes were investigated under transmission and scanning
electron microscopies. LipoRHIC and LipoRHIWC presented lower MIC, 5.5 and 12.5 𝜇g/mL, when compared to nonencapsulated
fractions (125 and 250 𝜇g/mL), respectively, and to ar-turmerone (50 𝜇g/mL). Parasite growth inhibition was demonstrated to be
dose-dependent. Important morphological changes as rounded body and presence of several roles on plasmatic membrane could be
seen on L. amazonensis promastigotes after treatment with subinhibitory concentration (2.75 𝜇g/mL) of the most active LipoRHIC.
In that sense, the hexane fraction from the turmeric cortex of Curcuma longa incorporated in liposomal formulation (LipoRHIC)
could represent good strategy for the development of new antileishmanial agent. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Departamento de Produtos Naturais. Laboratório de Plantas Medicinais e Derivados. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Amazonas. Departamento de Química. Laboratório de Cromatografia. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Departamento de Produtos Naturais. Laboratório de Plantas Medicinais e Derivados. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Departamento de Produtos Naturais. Laboratório de Plantas Medicinais e Derivados. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Produtos Naturais e Alimentos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Liposomal Formulation | pt_BR |
Subject | Turmerone-Rich Hexane Fractions | pt_BR |
Subject | Curcuma | pt_BR |
Subject | Antileishmanial Activity | pt_BR |