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https://www.arca.fiocruz.br/handle/icict/39840
GC-MS-FID CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF THE MIKANIA CORDIFOLIA ESSENTIAL OIL AND LIMONENE AGAINST MDR STRAINS
Author
Araújo, Ana Carolina Justino de
Freitas, Priscilla Ramos
Rodrigues dos Santos Barbosa, Cristina
Muniz, Débora Feitosa
Rocha, Janaína Esmeraldo
Albuquerque da Silva, Ana Cristina
Datiane de Morais Oliveira-Tintino, Cícera
Ribeiro Filho, Jaime
Everson da Silva, Luiz
Confortin, Camila
Amaral, Wanderlei do
Deschamps, Cícero
Barbosa Filho, José Maria
Ramos de Lima, Natanael Teles
Tintino, Saulo Relison
Melo Coutinho, Henrique Douglas
Freitas, Priscilla Ramos
Rodrigues dos Santos Barbosa, Cristina
Muniz, Débora Feitosa
Rocha, Janaína Esmeraldo
Albuquerque da Silva, Ana Cristina
Datiane de Morais Oliveira-Tintino, Cícera
Ribeiro Filho, Jaime
Everson da Silva, Luiz
Confortin, Camila
Amaral, Wanderlei do
Deschamps, Cícero
Barbosa Filho, José Maria
Ramos de Lima, Natanael Teles
Tintino, Saulo Relison
Melo Coutinho, Henrique Douglas
Affilliation
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
Federal University of Pernambuco. Department of Antibiotics. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Federal University of Paraná. Post Graduation Course of Sustainable Territorial Development. Matinhos, PR, Brazil.
Federal University of Paraná. Post Graduation Course of Sustainable Territorial Development. Matinhos, PR, Brazil.
Federal University of Paraná. Department of Chemical Technology. Curitiba, PR, Brazil.
Federal University of Paraná. Post Graduation Course of Agronomy. Curitiba, PR, Brazil.
Federal University of Paraiba. Department of Pharmacy. João Pessoa, PB, Brazil.
Federal University of Paraiba. Department of Pharmacy. João Pessoa, PB, Brazil.
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
Federal University of Pernambuco. Department of Antibiotics. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Federal University of Paraná. Post Graduation Course of Sustainable Territorial Development. Matinhos, PR, Brazil.
Federal University of Paraná. Post Graduation Course of Sustainable Territorial Development. Matinhos, PR, Brazil.
Federal University of Paraná. Department of Chemical Technology. Curitiba, PR, Brazil.
Federal University of Paraná. Post Graduation Course of Agronomy. Curitiba, PR, Brazil.
Federal University of Paraiba. Department of Pharmacy. João Pessoa, PB, Brazil.
Federal University of Paraiba. Department of Pharmacy. João Pessoa, PB, Brazil.
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
Abstract
The present study evaluated the effect of the essential oil of Mikania cordifolia (EOMc) and its major constituent limonene alone or associated with antibacterial drugs against Multidrug Resistant Bacteria (MDR). To evaluate the antibacterial activity, the minimum inhibitory concentrations (MIC) of the oil and limonene against Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus were determined. The antibiotic-modulating activity was assessed using subinhibitory concentrations (MIC/8) of these substances in combination with conventional antibacterial drugs. Although no relevant antibacterial activity of the natural products was detected, both substances modulated the action of antibiotics against resistant bacteria. The EOMc demonstrated the best modulating effect against P. aeruginosa, presenting synergistic effects when associated with gentamicin and norfloxacin. In addition, the oil reduced the MIC of norfloxacin against E. coli as well as reduced the MIC of gentamicin against S. aureus. On the other hand, the best effect of limonene was obtained against S. aureus. Thus, it is concluded that the essential oil Mikania cordifolia and the isolated compound limonene do not have clinically significant antibacterial effect, but modulate the action of antibiotics against MDR bacteria.
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