Author | Soilleux, E. J. | |
Author | Sarno, E. N. | |
Author | Hernandez, M. O. | |
Author | Moseley, E. | |
Author | Horsley, J. | |
Author | Lopes, U. G. | |
Author | Goddard, M. J. | |
Author | Vowler, S. L. | |
Author | Coleman, N. | |
Author | Shattock, R. J. | |
Author | Sampaio, E. P. | |
Access date | 2020-02-04T13:30:13Z | |
Available date | 2020-02-04T13:30:13Z | |
Document date | 2006 | |
Citation | SOILLEUX, EJ et al. DC-SIGN association with the Th2 environment of lepromatous lesions: cause or effect? Journal of Pathology, v. 209, p. 182-189, Mar. 2006. | pt_BR |
ISSN | 0022-3417 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/39705 | |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Mycobacterium leprae | pt_BR |
Subject in Portuguese | Hanseníase | pt_BR |
Subject in Portuguese | Macrófagos | pt_BR |
Title | DC-SIGN association with the Th2 environment of lepromatous lesions: cause or effect? | pt_BR |
Type | Article | pt_BR |
DOI | 10.1002/path.1972 | |
Abstract | The clinical spectrum of leprosy is related to patients' immune responses. Non-responsiveness towards Mycobacterium leprae (ML) seems to correlate with a Th2 cytokine profile. The reason for such a polarized immune response remains unclear. The C-type lectin, DC-SIGN, expressed by subsets of dendritic cells (DCs) and macrophages, has previously been associated with Th2 responses. Here we show abundant DC-SIGN expression in lepromatous but not borderline tuberculoid leprosy, in both HIV-positive and HIV-negative patients. Moreover, we demonstrate that DC-SIGN can act as an entry receptor for ML, as it does for M. tuberculosis, through the cell wall component lipoarabinomannan. DC-SIGN is expressed on virtually all ML-containing cells, providing further evidence for its role as a receptor. DC-SIGN may therefore be induced on macrophages in lepromatous leprosy and may then contribute to mycobacterial entry into these cells. | pt_BR |
Affilliation | Papworth Hospital. Department of Histopathology. Papworth Everard, Cambridge, UK / Medical Research Council Cancer Cell Unit. Hutchison/MRC Research Centre. Cambridge, UK / University of Oxford. Nuffield Department of Clinical Laboratory Sciences. Oxford, UK. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Papworth Hospital. Department of Histopathology. Papworth Everard, Cambridge, UK. | pt_BR |
Affilliation | Papworth Hospital. Department of Histopathology. Papworth Everard, Cambridge, UK. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Parasitologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Papworth Hospital. Department of Histopathology. Papworth Everard, Cambridge, UK. | pt_BR |
Affilliation | University of Cambridge Forvie Site. Department of Public Health and Primary Care. Centre for Applied Medical Statistics. Cambridge, UK. | pt_BR |
Affilliation | Medical Research Council Cancer Cell Unit. Hutchison/MRC Research Centre. Cambridge, UK. | pt_BR |
Affilliation | St. George’s Hospital Medical School. Department of Cellular and Molecular Medicine, Infectious Diseases. London, UK. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | DC-SIGN | pt_BR |
Subject | Macrophage | pt_BR |
Subject | ManLAM | pt_BR |
Subject | Leprosy | pt_BR |
Subject | M. leprae | pt_BR |
e-ISSN | 1096-9896 | |
Embargo date | 2025-01-01 | |