Author | Santos, Rafael Ribeiro | |
Author | Campos, Carli Salviana Maria de | |
Author | Ferretjans, Rodrigo | |
Author | Carvalho, Andrea Teixeira de | |
Author | Martins Filho, Olindo Assis | |
Author | Teixeira, Antonio Lucio | |
Author | Salgado, João Vinicius | |
Access date | 2020-02-03T13:48:42Z | |
Available date | 2020-02-03T13:48:42Z | |
Document date | 2019 | |
Citation | SANTOS, Rafael Ribeiro et al. The association of cognitive performance and IL-6 levels in schizophrenia is influenced by age and antipsychotic treatment. Nordic Journal of Psychiatry, v. 18, p. 1-7, 2019. | pt_BR |
ISSN | 0803-9488 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/39673 | |
Language | eng | pt_BR |
Publisher | Informa Healthcare | pt_BR |
Rights | restricted access | pt_BR |
Title | The association of cognitive performance and IL-6 levels in schizophrenia is influenced by age and antipsychotic treatment | pt_BR |
Type | Article | pt_BR |
DOI | 10.1080/08039488.2019.1688389 | |
Abstract | Aims: Recent findings suggest that cognitive impairment can be associated with inflammation and immune changes in schizophrenia. We aimed to study possible associations between cytokine levels and cognitive performance in a sample of patients with schizophrenia.Methods: Cognition was assessed with the brief assessment of cognition in schizophrenia in 63 clinically stable outpatients with schizophrenia. Blood was collected and cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, TNF-α, IFN-γ) were measured by cytometric bead array method. Psychopathological scales were also applied.Results: IL-6 correlated negatively with general cognitive performance (rho = -0.395, p = .017) and positively with antipsychotic dose (rho = 0.412, p = .004). Multiple regression analysis showed that cognitive performance is associated with age and antipsychotic dose (p = .000 and p = .033).Conclusion: The association between IL-6 levels and cognitive performance is dependent on age and antipsychotic dose. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Neurociência. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Neurociência. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Neurociência. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Neurociência. Belo Horizonte, MG, Brasil / Santa Casa BH Ensino e Pesquisa. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Neurociência. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, Brasil / Estado de Minas Gerais. Fundação Hospitalar. Hospital Psiquiátrico Raul Soares. Belo Horizonte, MG, Brasil. | pt_BR |
Subject | IL-6 | pt_BR |
Subject | Schizophrenia | pt_BR |
Subject | Cognition | pt_BR |
Subject | Inflammation | pt_BR |
Embargo date | 2040-01-01 | |