Author | Tschá, Marcel Kruchelski | |
Author | Suzukawa, Andreia Akemi | |
Author | Gräf, Tiago | |
Author | Piancini, Laercio Dante Stein | |
Author | Silva, Allan Martins da | |
Author | Faoro, Helisson | |
Author | Riediger, Irina Nastassja | |
Author | Medeiros, Lia Carolina | |
Author | Wowk, Pryscilla Fanini | |
Author | Zanluca, Camila | |
Author | Santos, Claudia Nunes Duarte dos | |
Access date | 2020-01-29T19:10:22Z | |
Available date | 2020-01-29T19:10:22Z | |
Document date | 2019 | |
Citation | TSCHÁ, Marcel Kruchelski et al. Identification of a novel alphavirus related to the encephalitis complexes circulating in southern Brazil. Emerging Microbes & Infections, v. 8, p. 1-15, 2019. | pt_BR |
ISSN | 2222-1751 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/39613 | |
Sponsorship | CNPq (Conselho Nacional
de Desenvolvimento Científico e Tecnológico, Brazil) and
Fiocruz (Fundação Oswaldo Cruz). CNDS is a recipient of
a CNPq fellowship. | pt_BR |
Language | eng | pt_BR |
Publisher | Taylor & Francis | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Vírus Caainguá | pt_BR |
Subject in Portuguese | Vírus associado a Culex | pt_BR |
Subject in Portuguese | Mosquito | pt_BR |
Subject in Portuguese | Novo alfavírus | pt_BR |
Subject in Portuguese | Sul do Brasil | pt_BR |
Title | Identification of a novel alphavirus related to the encephalitis complexes circulating in southern Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.1080/22221751.2019.1632152 | |
Abstract | In early 2017, an outbreak caused by an unknown and supposedly viral agent in the Marilena region of southern Brazil was investigated. Since the etiological agent causing the outbreak was not identified from human samples, mosquitoes from this region were collected. Three out of 121 mosquito pools collected from the region tested positive for alphavirus in molecular tests. Next generation sequencing results revealed the presence of a novel alphavirus, tentatively named here as Caainguá virus (CAAV). DNA barcoding analyses indicated that different species of Culex are hosts for CAAV. This new virus was basal to the New World encephalitic alphaviruses in a comprehensive and robust phylogenetic approach using complete genomes. Viral particles were observed in the cytosol and inside of intracellular compartments of cells in mosquito-derived cell cultures. Despite being noninfectious in vertebrate derived cell cultures, primary culturing of CAAV in human mononuclear cells suggests monocytes and lymphocytes as CAAV targets. However, the epidemiological link of CAAV on the human outbreak should be further explored. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Secretaria da Saúde do Estado do Paraná. Laboratório Central. São José dos Pinhais, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Secretaria da Saúde do Estado do Paraná. Laboratório Central. São José dos Pinhais, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Celular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Subject | Caainguá virus | pt_BR |
Subject | Culex-associated virus | pt_BR |
Subject | Mosquito | pt_BR |
Subject | New alphavirus | pt_BR |
Subject | South Brazil | pt_BR |