Author | Duarte, Stenio Fernando Pimentel | |
Author | Francischetti, Emílio Antonio | |
Author | Abreu, Virgínia Genelhu | |
Author | Barroso, Sergio Girão | |
Author | Braga, José Uéleres | |
Author | Cabello, Pedro Hernan | |
Author | Pimentel, Márcia Mattos Gonçalves | |
Access date | 2020-01-16T13:27:13Z | |
Available date | 2020-01-16T13:27:13Z | |
Document date | 2006 | |
Citation | DUARTE, Stenio Fernando Pimentel et al. p.Q223R Leptin Receptor Polymorphism Associated with Obesity in Brazilian Multiethnic Subjects. American Journal of Human Biology, v. 18, p. 448-453, 2006. | pt_BR |
ISSN | 1042-0533 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/39255 | |
Language | eng | pt_BR |
Publisher | Wiley 12 Months | pt_BR |
Rights | restricted access | |
Subject in Portuguese | Polimorfismo | pt_BR |
Subject in Portuguese | Receptor de leptina p.Q223R | pt_BR |
Subject in Portuguese | Obesidade | pt_BR |
Subject in Portuguese | Pessoas multiétnicas | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Title | p.Q223R Leptin Receptor Polymorphism Associated with Obesity in Brazilian Multiethnic Subjects | pt_BR |
Type | Article | |
DOI | 10.1002/ajhb.20519 | |
Abstract | Several genes play a major role in obese phenotypes, and studies suggest that
genetic variations among individuals, as well as their lifestyles, may bring about different body
compositions. Among these genes, LEP, which codifies leptin, and the LEPR gene encoding its receptor
were extensively studied for variants that could explain the obese phenotype. The LEPR
p.Q223R gene polymorphism was analyzed in a sample of obese and nonobese individuals from
Brazil to evaluate the role of this polymorphism in the obese phenotype in the population. Two
hundred obese patients (60 males, 140 females, body mass index (BMI) >30 kg/m2) were screened,
together with 150 lean or normal healthy individuals (63 males, 87 females, BMI <24 kg/m2).
Genomic DNA was extracted and amplified by polymerase chain reaction (PCR). PCR products
were digested with the restriction of endonuclease MspI, and separated by electrophoresis
through an 8% polyacrilamide gel stained with silver nitrate. There was a significant difference
in LEPR p.Q223R polymorphism frequency when comparing obese and lean subjects, with an
odds ratio of 1.92 and a 95% confidence interval of 1.15–3.22 (P ¼ 0.013). There is a strong association
of the LEPR p.Q223R gene polymorphism with obesity in Brazil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Departamento de Biologia Celular e Genética. Serviço de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Clínica de Hipertensão. Laboratório de Fisiopatologia Clínica e Experimental. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Clínica de Hipertensão. Laboratório de Fisiopatologia Clínica e Experimental. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Clínica de Hipertensão. Laboratório de Fisiopatologia Clínica e Experimental. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Clínica de Hipertensão. Laboratório de Fisiopatologia Clínica e Experimental. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Departamento de Biologia Celular e Genética. Serviço de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Polymorphism | pt_BR |
Subject | p.Q223R Leptin Receptor | pt_BR |
Subject | Obesity | pt_BR |
Subject | Multiethnic Subjects | pt_BR |
Subject | Brazil | pt_BR |
e-ISSN | 1520-6300 | |