Author | Cataneo, Allan Henrique Depieri | |
Author | Kuczera, Diogo | |
Author | Koishi, Andrea Cristine | |
Author | Zanluca, Camila | |
Author | Silveira, Guilherme Ferreira | |
Author | Arruda, Thaís Bonato de | |
Author | Suzukawa, Andréia Akemi | |
Author | Bortot, Leandro Oliveira | |
Author | Dias-Baruffi, Marcelo | |
Author | Verri, Waldiceu Aparecido | |
Author | Robert, Anny Waloski | |
Author | Stimamiglio, Marco Augusto | |
Author | Santos, Claudia Nunes Duarte dos | |
Author | Wowk, Pryscilla Fanini | |
Author | Bordignon, Juliano | |
Access date | 2019-12-18T20:05:03Z | |
Available date | 2019-12-18T20:05:03Z | |
Document date | 2019 | |
Citation | CATANEO, Allan Henrique Depieri et al. The citrus favonoid naringenin impairs the in vitro infection of human cells by Zika virus. Scientific Reports, v. 9, n. 16348, p. 1-15, 2019. | pt_BR |
ISSN | 2045-2322 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/38694 | |
Language | por | pt_BR |
Publisher | Nature Research | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Zika virus | pt_BR |
Title | The citrus flavonoid naringenin impairs the in vitro infection of human cells by Zika virus | pt_BR |
Type | Article | pt_BR |
DOI | 10.1038/s41598-019-52626-3 | |
Abstract | The Zika virus (ZIKV) is an arthropod-borne virus that belongs to the Flaviviridae family. The ZIKV infection is usually asymptomatic or is associated with mild clinical manifestations; however, increased numbers of cases of microcephaly and birth defects have been recently reported. To date, neither a vaccine nor an antiviral treatment has become available to control ZIKV replication. Among the natural compounds recognized for their medical properties, flavonoids, which can be found in fruits and vegetables, have been found to possess biological activity against a variety of viruses. Here, we demonstrate that the citrus flavanone naringenin (NAR) prevented ZIKV infection in human A549 cells in a concentration-dependent and ZIKV-lineage independent manner. NAR antiviral activity was also observed when primary human monocyte-derived dendritic cells were infected by ZIKV. NAR displayed its antiviral activity when the cells were treated after infection, suggesting that NAR acts on the viral replication or assembly of viral particles. Moreover, a molecular docking analysis suggests a potential interaction between NAR and the protease domain of the NS2B-NS3 protein of ZIKV which could explain the anti-ZIKV activity of NAR. Finally, the results support the potential of NAR as a suitable candidate molecule for developing anti-ZIKV treatments. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Física e Química. Laboratório de Física Biológica. Ribeirão Preto, São Paulo, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Laboratório de Glicoimunologia. Ribeirão Preto, São Paulo, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Londrina, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Células Tronco. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Células Tronco. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Subject | Zika Virus | pt_BR |
Subject | Flavonoids | pt_BR |
Subject | therapy | pt_BR |
Subject | Flavanones | pt_BR |
Subject in Spanish | Virus Zika | pt_BR |
DeCS | Flavonoides | pt_BR |
DeCS | terapia | pt_BR |
DeCS | Flavanonas | pt_BR |
e-ISSN | 2045-2322 | |