Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/3821
Title: Production of septal fibrosis of the liver by means of foreign protein injections into rats.
Authors: Gotardo, Bruna Magalhães
Andrade, Rodrigo Guimarães
Oliveira, Ludmila Fernandes
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Abstract: Para se investigar o potencial fibrogênico de materiais derivados da Capillaria hepatica foi feita uma tentativa para se induzir fibrose hepática septal em ratos, através de injeções intraperitoneais repetidas de um extrato de fígado de camundongo infectado pela Capillaria hepática. Dois dos 10 ratos assim tratados desenvolveram fibrose. Comparativamente, 4 dos 9 ratos que receberam injeções de soro de porco desenvolveram fibrose septal do fígado, enquanto nenhuma fibrose apareceu em 10 ratos tratados com extratos de fígado normal de camundongo. Uma vez que, na infecção natural de ratos pela Capillaria hepatica, a fibrose aparece em 100% dos casos, fica evidente que a administração intraperitoneal de uma substância não revela inteiramente o seu potencial fibrogênico
Abstract: Similarities and differences in antigenic humoral responses and electrophoretic patterns between Capillaria hepatica and pig-serum were investigated as a contribution to the understanding of hepatic fibrosis induced by the parenteral administration of foreign proteins. Only two out of 10 rats receiving repeated intraperitoneal injections of an extract of Capillaria hepatica-infected mouse liver presented septal hepatic fibrosis (20%). Under the same experimental conditions, 4 out of 9 rats (44.4%) developed septal fibrosis following whole pig-serum administration. Injections of normal mouse liver extracts did not result in hepatic fibrosis. Since a 100% septal fibrosis rate is observed in experimentally Capillaria hepatica-infected rats, it appeared that Capillaria hepatica products continuously released from inside the liver creates a much more effective fibrosis inducing mechanism than the parenteral administration of such factors. Thus, repeated peritoneal administration of a foreign protein to rats would not reveal the full fibrogenic potential it may have under natural conditions.
Keywords: Capillaria hepatica
Modelo do soro de porco
Fibrose septal hepática
DeCS: Capillaria
Proteínas de Helminto
Cirrose Hepática Experimental
Hepatopatias Parasitárias
Capillaria
Modelos Animais de Doenças
Cirrose Hepática Experimental
Hepatopatias Parasitárias
Camundongos
Ratos Wistar
Issue Date: 2003
Citation: GOTARDO, B.M. et al. Production of septal fibrosis of the liver by means of foreign protein injections into rats. Revista da Sociedade Brasileira de Medicina Tropical de São Paulo, v. 36, n. 5, p. 577-80, sep.-out. 2003.
ISSN: 0037-8682
Appears in Collections:IGM - Artigos de Periódicos

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