Author | Malfussi, Hamilton | |
Author | Santana, Iara Vidigal | |
Author | Gasparotto, Juciano | |
Author | Righy, Cassia | |
Author | Tomasi, Cristiane Damiani | |
Author | Gelain, Daniel Pens | |
Author | Bozza, Fernando A. | |
Author | Walz, Roger | |
Author | Dal-Pizzol, Felipe | |
Author | Ritter, Cristiane | |
Access date | 2019-12-12T15:16:33Z | |
Available date | 2019-12-12T15:16:33Z | |
Document date | 2019 | |
Citation | MALFUSSI, Hamilton et al. Anti-NMDA receptor autoantibody is an independent predictor of hospital mortality but not brain dysfunction in septic patients. Frontiers in Neurology, p. 1-6, v. 10, Mar. 2019. | pt_BR |
ISSN | 1664-2295 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/37907 | |
Language | eng | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Title | Anti-NMDA receptor autoantibody is an independent predictor of hospital mortality but not brain dysfunction in septic patients | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fneur.2019.00221 | |
Abstract | The presence of autoantibodies against neuronal cell surface or synaptic proteins and their relationship to autoimmune encephalitis have recently been characterized. These autoantibodies have been also reported in other pathologic conditions; however, their role during sepsis is not known. This study detected the presence of autoantibodies against neuronal cell surface or synaptic proteins in the serum of septic patients and determined their relationship to the occurrence of brain dysfunction and mortality. This prospective, observational cohort study was performed in four Brazilian intensive care units (ICUs). Sixty patients with community-acquired severe sepsis or septic shock admitted to the ICU were included. Blood samples were collected from patients within 24 h of ICU admission. Antibodies to six neuronal proteins were assessed, including glutamate receptors (types NMDA, AMPA1, and AMPA2); voltage-gated potassium channel complex (VGKC) proteins, leucine-rich glioma-inactivated protein 1 (LGI1), and contactin-associated protein-2 (Caspr2), as well as the GABAB1 receptor. There was no independent association between any of the measured autoantibodies and the occurrence of brain dysfunction (delirium or coma). However, there was an independent and significant relationship between anti-NMDAR fluorescence intensity and hospital mortality. In conclusion, anti-NMDAR was independently associated with hospital mortality but none of the measured antibodies were associated with brain dysfunction in septic patients. | pt_BR |
Affilliation | Universidade Federal de Santa Catarina. Programa de Pós-Graduação em Ciências Médicas. Florianópolis, SC, Brasil. | pt_BR |
Affilliation | Universidade do Extremo Sul Catarinense. Laboratório de Fisiopatologia Experimental. Criciúma, SC, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio Grande do Sul. Centro de Estudos em Estresse Oxidativo. Instituto de Ciências Básicas da Saúde. Departamento de Bioquímica. Porto Alegre, RS, Brasil. | pt_BR |
Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Extremo Sul Catarinense. Laboratório de Fisiopatologia Experimental. Criciúma, SC, Brasil / Universidade do Extremo Sul Catarinense. Grupo de Pesquisa em Gestão do Cuidado, Integralidade e Educação na Saúde. Programa de Pós-Graduação em Saúde Coletiva. Criciúma, SC, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio Grande do Sul. Centro de Estudos em Estresse Oxidativo. Instituto de Ciências Básicas da Saúde. Departamento de Bioquímica. Porto Alegre, RS, Brasil. | pt_BR |
Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil / Instituto D'Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Centro de Cirurgia de Epilepsia de Santa Catarina. Departamento de Clínica Médica. Serviço de Neurologia. Florianópolis, SC, Brasil / Universidade Federal de Santa Catarina. Hospital Universitário. Centro de Neurociências Aplicadas. Florianópolis, SC, Brasil. | pt_BR |
Affilliation | Universidade do Extremo Sul Catarinense. Laboratório de Fisiopatologia Experimental. Criciúma, SC, Brasil / Hospital São José. Criciúma, SC, Brasil. | pt_BR |
Affilliation | Universidade do Extremo Sul Catarinense. Laboratório de Fisiopatologia Experimental. Criciúma, SC, Brasil / Hospital São José. Criciúma, SC, Brasil. | pt_BR |
Subject | Delirium | pt_BR |
Subject | Brain dysfunction | pt_BR |
Subject | Sepsis | pt_BR |
Subject | Neuronal autoantibodies | pt_BR |
Subject | ICU | pt_BR |
e-ISSN | 1664-2295 | |