Author | Lenzi, Henrique Leonel | |
Author | Romanha, Waldemiro de Souza | |
Author | Santos, R. M. Zorzenon dos | |
Author | Rosas, A. | |
Author | Mota, Ester Maria | |
Author | Manso, Pedro Paulo de Abreu | |
Author | Caputo, Luzia F. G. | |
Author | Machado, Marcelo Pelajo | |
Access date | 2012-01-27T14:58:48Z | |
Available date | 2012-01-27T14:58:48Z | |
Document date | 2006 | |
Citation | LENZI, H. L. et al. Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure. Memórias do Instituto Oswaldo Cruz, v.101, supl.1, p. 219-231, 2006. | pt_BR |
ISSN | 0074-0276 | |
URI | https://www.arca.fiocruz.br/handle/icict/3747 | |
Sponsorship | Financial support: CNPq, Fiocruz | pt_BR |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | p |
Rights | open access | pt_BR |
Title | Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure | pt_BR |
Type | Article | pt_BR |
DOI | http://dx.doi.org/10.1590/S0074-02762006000900034. | |
Abstract | This paper centers on some whole-istic organizational and functional aspects of hepatic Schistosoma mansoni granuloma, which is an extremely complex system. First, it structurally develops a collagenic topology, originated bidirectionally from an inward and outward assembly of growth units. Inward growth appears to be originated from myofibroblasts derived from small portal vessel around intravascular entrapped eggs, while outward growth arises from hepatic stellate cells. The auto-assembly of the growth units defines the three-dimensional scaffold of the schistosome granulomas. The granuloma surface irregularity and its border presented fractal dimension equal to 1.58. Second, it is internally regulated by intricate networks of immuneneuroendocrine stimuli orchestrated by leptin and leptin receptors, substance P and Vasoactive intestinal peptide. Third, it can reach the population of ± 40,000 cells and presents an autopoietic component evidenced by internal proliferation (Ki-67+ Cells), and by expression of c-Kit+ Cells, leptin and leptin receptor (Ob-R), granulocyte-colony stimulating factor (G-CSF-R), and erythropoietin (Epo-R) receptors. Fourth, the granulomas cells are intimately connected by pan-cadherins, occludin and connexin-43, building a state of closing (granuloma closure). In conclusion, the granuloma is characterized by transitory stages in such a way that its organized structure emerges as a global property which is greater than the sum of actions of its individual cells and extracellular matrix components. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal de Pernambuco. Departamento de Física. Recife, PE, Brasil | pt_BR |
Affilliation | Universidade Federal da Paraíba. Departamento de Física. João Pessoa, PB, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Subject | Schistosoma mansoni | pt_BR |
Subject | granuloma | pt_BR |
Subject | Fractal | pt_BR |
Subject | Leptin | pt_BR |
Subject | Ocludin | pt_BR |
Subject | Connexin-43 | pt_BR |
DeCS | Schistosoma mansoni | pt_BR |
DeCS | Granuloma | pt_BR |
DeCS | Leptina | pt_BR |
DeCS | Patologia | pt_BR |
DeCS | Parasitologia | pt_BR |
DeCS | Metabolismo | pt_BR |
DeCS | Fatores de Tempo | pt_BR |
DeCS | Modelos Animais de Doenças | pt_BR |