Author | De-La-Torre, Alejandra | |
Author | Stanford, Miles | |
Author | Curi, André | |
Author | Jaffe, Glenn J. | |
Author | Gomez-Marin, Jorge E. | |
Access date | 2019-11-18T14:34:02Z | |
Available date | 2019-11-18T14:34:02Z | |
Document date | 2011 | |
Citation | DE-LA-TORRE, Alejandra et al. Therapy for ocular toxoplasmosis. Ocular Immunology and Inflammation, v. 19, n. 5, p. 314-320, 2011. | pt_BR |
ISSN | 0927-3948 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/37117 | |
Language | eng | pt_BR |
Publisher | Taylor & Francis | pt_BR |
Rights | open access | pt_BR |
Title | Therapy for ocular toxoplasmosis | pt_BR |
Type | Article | pt_BR |
DOI | 10.3109/09273948.2011.608915 | |
Abstract | Purpose: To review current evidence for the treatment of ocular toxoplasmosis (OT). Design: Narrative review and expert recommendations. Methods: Meta-analysis and selected original articles from the medical literature were reviewed critically. Expert recommendations were analyzed. Results: Numerous observational studies suggest a benefit of short-term antimicrobial therapy for toxoplasmic retinochoroiditis in immunocompetent patients, although its efficacy has not been proven in randomized clinical trials. A randomized clinical trial revealed that intermittent trimethoprim/sulfamethoxazole treatment could decrease the rate of recurrence in high-risk patients. Intravitreal injection of clindamycin and dexamethasone was an acceptable alternative to the classic treatment for OT in a randomized clinical trial. Conclusions: Opinions about therapy differ and controversy remains about its type, efficacy, and length. Intravitreal therapy may be promising for OT. A recent description of the presence of parasitemia in patients with active and inactive ocular toxoplasmosis raises new questions that need to be explored. | pt_BR |
Affilliation | Universidad del Quindío. Centro de Investigaciones Biomédicas. Grupo de Estudio en Parasitología Molecular. Armenia, Colombia. | pt_BR |
Affilliation | King’s College London. St. Thomas’ Campus. Rayne Institute, Department of Academic Ophthalmology. London, UK. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Duke Eye Center. Duke Reading Center. Durham, NC, USA. | pt_BR |
Affilliation | Universidad del Quindío. Centro de Investigaciones Biomédicas. Grupo de Estudio en Parasitología Molecular. Armenia, Colombia. | pt_BR |
Subject | Antibiotics | pt_BR |
Subject | Ocular toxoplasmosis | pt_BR |
Subject | Recurrences | pt_BR |
Subject | Steroids | pt_BR |
Subject | Therapy | pt_BR |
Subject | Treatment | pt_BR |
Subject | Uveitis | pt_BR |
e-ISSN | 1678-8060 | |
Embargo date | 2020-11-18 | |