Author | Farias, Isabela Cristina Cordeiro | pt_BR |
Author | Belmont, Taciana Furtado de Mendonça | pt_BR |
Author | Silva, Andreia Soares da | pt_BR |
Author | Ó, Kleyton Palmeira do | pt_BR |
Author | Ferreira, Felipe Roberto Borba | pt_BR |
Author | Medeiros, Fernanda Silva | pt_BR |
Author | Vasconcelos, Luydson Richardson Silva | pt_BR |
Author | Bezerra, Marcos Andre Cavalcanti | pt_BR |
Author | Araújo, Aderson da Silva | pt_BR |
Author | Moura, Patrícia Muniz Mendes Freire de | pt_BR |
Author | Hatzlhofer, Betânia Lucena Domingues | pt_BR |
Author | Anjos, Ana Cláudia Mendonça dos | pt_BR |
Author | Cavalcanti, Maria do Socorro de Mendonça | pt_BR |
Access date | 2019-11-18T13:55:11Z | |
Available date | 2019-11-18T13:55:11Z | |
Document date | 2018 | |
Citation | FARIAS, Isabela Cristina Cordeiro et al. Association of the SOD2 polymorphism (Val16Ala) and SOD activity with vasoocclusive crisis and acute splenic sequestration in children with sickle cell anemia. Mediterranean Journal of Hematology and Infectious Diseases, v. 10, p. 1-5, 21 Feb. 2018. | pt_BR |
ISSN | 2035-3006 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/37113 | |
Sponsorship | FACEPE | pt_BR |
Language | eng | en |
Publisher | PAGEpress | pt_BR |
Rights | open access | pt_BR |
Title | Association of the SOD2 polymorphism (Val16Ala) and SOD activity with vasoocclusive crisis and acute splenic sequestration in children with sickle cell anemia | en |
Type | Article | pt_BR |
DOI | 10.4084/MJHID.2018.012 | pt_BR |
Abstract | The SOD2 polymorphism Val16Ala T→C influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with the vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children with SCA aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC and CC were more frequent in patients with VOC or ASS (p=0.0285; p=0.0090, respectively). These results suggest that the SOD2 polymorphism associated with low SOD activity could be a susceptibility factor for the occurrence of VOC and ASS. | en |
Affilliation | Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil / Universidade Federal Rural de Pernambuco. Programa de Pós-Graduação em Biotecnologia. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Pernambuco. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Pernambuco. Recife, PE, Brasil / Fundação de Hematologia e Hemoterapia de Pernambuco. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação de Hematologia e Hemoterapia de Pernambuco. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Pernambuco. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação de Hematologia e Hemoterapia de Pernambuco. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil / Fundação de Hematologia e Hemoterapia de Pernambuco. Recife, PE, Brasil. | pt_BR |
Subject | MnSOD | en |
Subject | Sickle cell anemia | en |
Subject | Vaso-occlusive events | en |
DeCS | Superóxido Dismutase | pt_BR |
DeCS | Anemia Falciforme | pt_BR |