Author | Nascimento, Clarissa Rodrigues | |
Author | Lima, Marco Antonio | |
Author | Serpa, Maria José de Andrada | |
Author | Espindola, Otávio | |
Author | Leite, Ana Claudia Celestino | |
Author | Echevarria-Lima, Juliana | |
Access date | 2019-11-06T15:00:07Z | |
Available date | 2019-11-06T15:00:07Z | |
Document date | 2011 | |
Citation | NASCIMENTO, Clarissa Rodrigues et al. Monocytes from HTLV-1–infected patients are unable to fully mature into dendritic cells. Immunobiology, v. 117, n. 2, p. 489-499, Jan. 2011. | pt_BR |
ISSN | 0171-2985 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/36902 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | Monocytes from HTLV-1 infected patients are unable to fully maturate into dendritic cells | pt_BR |
Type | Article | pt_BR |
DOI | 10.1182/blood-2010-03-272690 | |
Abstract | Human T-cell lymphotropic virus type 1 (HTLV-1) is a causative agent of adult T-cell leukemia and HTLV-1–associated myelopathy/tropical spastic paraparesis. HTLV-1–associated myelopathy/tropical spastic paraparesis is a chronic inflammatory disease characterized by loss of motor movement in response to spinal marrow cell destruction by T lymphocytes. To perform their cellular function, T cells need to be activated by antigenpresenting cells, such as dendritic cells (DCs). The aim of this work was to analyze DC differentiation and activation from monocytes of HTLV-1–infected individuals. We demonstrated that monocytes from HTLV-1–infected patients who had been stimulated to differentiate had an impaired loss of CD14 expression, expressed low levels of CD1a, and maintained secretion of tumor necrosis factor- compared with monocytes from
noninfected donors. We further evaluated DC activation by tumor necrosis factor- α. We observed that in response to activation, DCs that were derived from noninfected donors had an increase in the percentage of CD83, CD86, and human leukocyte antigen-DR cells, whereas in DCs derived from HTLV-1–infected patients, the percentage of CD83, CD86, and human leukocyte antigen-DR cells remained similar to that of nonactivated cells. Moreover, these cells had an impaired capacity to stimulate allogeneic T lymphocytes. We demonstrated that DC maturation was altered in HTLV-1– infected patients, which could contribute to the development of HTLV-1–associated diseases. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Laboratório de Imunologia Tumoral do Instituto de Bioquímica Médica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfeçcões. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa em Patogenia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa em Patogenia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfeçcões. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Departamento de Imunologia do Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil. | pt_BR |
Embargo date | 2020-11-06 | |