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2020-01-06
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POTENTIAL ROLE OF HEDGEHOG SIGNALING PATHWAY AND MYOFIBROBLASTIC DIFFERENTIATION IN CENTRAL GIANT CELL GRANULOMA-A PRELIMINARY STUDY
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Affilliation
Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduation. Salvador, BA, Brazil.
University of São Paulo. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology. São Paulo, SP, Brazil.
Federal University of Bahia. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology. Salvador, BA, Brazil.
Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduation. Salvador, BA, Brazil.
Federal University of Rio Grande do Norte. School of Dentistry. Laboratory of Oral and Maxillofacial
Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduation. Salvador, BA, Brazil.
Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduation. Salvador, BA, Brazil.
Federal University of Bahia. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology. Salvador, BA, Brazil.
University of São Paulo. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology. São Paulo, SP, Brazil.
Federal University of Bahia. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology. Salvador, BA, Brazil.
Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduation. Salvador, BA, Brazil.
Federal University of Rio Grande do Norte. School of Dentistry. Laboratory of Oral and Maxillofacial
Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduation. Salvador, BA, Brazil.
Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduation. Salvador, BA, Brazil.
Federal University of Bahia. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology. Salvador, BA, Brazil.
Abstract
This study investigated components of the Hedgehog (HH) signaling pathway (SHH, GLI1), cyclin D1, and smooth muscle actin (SMA) in central giant cell granulomas (CGCG). The relationship between these proteins and myofibroblasts was also studied. Material and methods: Twelve cases of non‐aggressive CGCG and 11 cases of aggressive
CGCG were studied using immunohistochemistry for SHH, GLI1, Cyclin D1,
and SMA.
Results: Associations between all proteins in non‐aggressive and aggressive CGCG were
not significant (P > .05). All cases of CGCG showed significantly higher expression of SMA
compared with the other proteins (P < .01). A positive correlation (P = .04) was only observed
between SHH and GLI1 for all cases of CGCG. Furthermore, a positive correlation
between SHH and GLI1 in non‐aggressive CGCG (P = .04) and between GLI1 and cyclin
D1 in aggressive CGCG (P = .03) were observed. There was also a negative correlation
between the expression of SHH and SMA in non‐aggressive CGCG (P = .031).
Conclusions: This study provided insights into the activation of the HH signaling
pathway in CGCG. In addition, the activation of this pathway (SHH and GLI1)
might play some role in the differentiation of stromal myofibroblasts, although these
markers including Cyclin D1 and SMA do not indicate aggressiveness of the CGCG.
Furthermore, this myofibroblastic differentiation process would occur at the expense
of maturation of these lesions.
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