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https://www.arca.fiocruz.br/handle/icict/36325
RISK OF ZIKA MICROCEPHALY CORRELATES WITH FEATURES OF MATERNAL ANTIBODIES
Author
Robbiani, Davide F.
Olsen, Priscilla C.
Costa, Federico
Wang, Qiao
Oliveira, Thiago Yukio
Nery, Nivison
Aromolaran, Adeolu
Rosário, Mateus Santana do
Sacramento, Gielson Almeida do
Cruz, Jaqueline Silva
Cunha, Antonio Ricardo Khouri
Wunder Junior, Elsio Augusto
Mattos, Adriana
Freitas, Bruno de Paula
Sarno, Manoel
Archanjo, Gracinda
Daltro, Dina
Carvalho, Gustavo B. S.
Pimentel, Kleber
Siqueira, Isadora Cristina de
Almeida, João R. M. de
Henriques, Daniele Freitas
Lima, Juliana A.
Vasconcelos, Pedro F. C.
Babajew, Dennis Schaefer
Azzopardi, Stephanie A.
Bozzacco, Leonia
Gazumyan, Anna
Belfort, Rubens
Alcântara, Ana P.
Carvalho, Gustavo
Moreira, Licia
Araujo, Katiaci
Reis, Mitermayer Galvão dos
Keesler, Rebekah I.
Coffey, Lark L.
Tisoncik-Go, Jennifer
Gale, Michael
Rajagopal, Lakshmi
Waldorf, Kristina M. Adams
Dudley, Dawn M.
Simmons, Heather A.
Mejia, Andres
O'Connor, David H.
Steinbach, Rosemary J.
Haese, Nicole
Smith, Jessica
Lewis, Anne
Colgin, Lois
Roberts, Victoria
Frias, Antonio
Kelleher, Meredith
Hirsch, Alec
Streblow, Daniel N.
Rice, Charles M.
MacDonald, Margaret R.
Almeida, Antonio R. P. de
Van Rompay, Koen K. A.
Ko, Albert Icksang
Nussenzweig, Michel C.
Olsen, Priscilla C.
Costa, Federico
Wang, Qiao
Oliveira, Thiago Yukio
Nery, Nivison
Aromolaran, Adeolu
Rosário, Mateus Santana do
Sacramento, Gielson Almeida do
Cruz, Jaqueline Silva
Cunha, Antonio Ricardo Khouri
Wunder Junior, Elsio Augusto
Mattos, Adriana
Freitas, Bruno de Paula
Sarno, Manoel
Archanjo, Gracinda
Daltro, Dina
Carvalho, Gustavo B. S.
Pimentel, Kleber
Siqueira, Isadora Cristina de
Almeida, João R. M. de
Henriques, Daniele Freitas
Lima, Juliana A.
Vasconcelos, Pedro F. C.
Babajew, Dennis Schaefer
Azzopardi, Stephanie A.
Bozzacco, Leonia
Gazumyan, Anna
Belfort, Rubens
Alcântara, Ana P.
Carvalho, Gustavo
Moreira, Licia
Araujo, Katiaci
Reis, Mitermayer Galvão dos
Keesler, Rebekah I.
Coffey, Lark L.
Tisoncik-Go, Jennifer
Gale, Michael
Rajagopal, Lakshmi
Waldorf, Kristina M. Adams
Dudley, Dawn M.
Simmons, Heather A.
Mejia, Andres
O'Connor, David H.
Steinbach, Rosemary J.
Haese, Nicole
Smith, Jessica
Lewis, Anne
Colgin, Lois
Roberts, Victoria
Frias, Antonio
Kelleher, Meredith
Hirsch, Alec
Streblow, Daniel N.
Rice, Charles M.
MacDonald, Margaret R.
Almeida, Antonio R. P. de
Van Rompay, Koen K. A.
Ko, Albert Icksang
Nussenzweig, Michel C.
Affilliation
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA / Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.
Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven / Universidade Federal da Bahia. Faculdade de Medicina. Instituto da Saúde Coletiva. Salvador, BA, Brasil.
Fudan University. School of Basic Medical Sciences. Shanghai Medical College. Key Laboratory of Medical Molecular Virology. Shanghai, China.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven.
Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven.
Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.
Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil / Universidade Federal de São Paulo. São Paulo, SP, Brasil.
Universidade Federal da Bahia. Faculdade de Medicina. Instituto da Saúde Coletiva. Salvador, BA, Brasil.
Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.
Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.
Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.
Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Universidade Federal da Bahia. Faculdade de Medicina. Instituto da Saúde Coletiva. Salvador, BA, Brasil.
Ministério da Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Ministério da Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Ministério da Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY.
Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA.
Universidade Federal de São Paulo. São Paulo, SP, Brasil.
Hospital Santo Amaro. Salvador, BA, Brasil.
Hospital Santo Amaro. Salvador, BA, Brasil.
Hospital Santo Amaro. Salvador, BA, Brasil.
Hospital Aliança. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven / Universidade Federal da Bahia. Faculdade de Medicina. Instituto da Saúde Coletiva. Salvador, BA, Brasil.
University of California. California National Primate Research Center. Davis, Davis, CA, USA.
University of California. School of Veterinary Medicine. Department of Pathology, Microbiology, and Immunology. Davis, Davis, CA, USA.
Washington National Primate Research Center. Seattle, WA, USA / University of Washington. Center for Innate Immunity and Immune Disease. Seattle, WA, USA / University of Washington. Department of Immunology. Seattle, WA, USA.
Washington National Primate Research Center. Seattle, WA / University of Washington. Center for Innate Immunity and Immune Disease. Seattle, WA, USA / University of Washington. Department of Immunology. Seattle, WA, USA / University of Washington. Department of Global Health. Seattle, WA, USA.
University of Washington. Department of Global Health. Seattle, WA, USA / University of Washington. Department of Pediatrics. Seattle, WA, USA / Seattle Children’s Research Institute. Center for Global Infectious Disease Research. Seattle, WA, USA.
Washington National Primate Research Center. Seattle, WA, USA / University of Washington. Center for Innate Immunity and Immune Disease. Seattle, WA, USA / University of Washington. Department of Global Health. Seattle, WA, USA / University of Washington. Department of Obstetrics and Gynecology. Seattle, WA, USA.
University of Wisconsin-Madison. Department of Pathology and Laboratory Medicine. Madison, WI, USA.
University of Wisconsin-Madison. Wisconsin National Primate Research Center. Madison, WI, USA.
University of Wisconsin-Madison. Wisconsin National Primate Research Center. Madison, WI, USA.
University of Wisconsin-Madison. Department of Pathology and Laboratory Medicine. Madison, WI, USA.
Oregon National Primate Research Center. Division of Reproductive and Developmental Sciences. Beaverton, OR, USA.
Oregon National Primate Research Center. Division of Pathobiology and Immunology. Beaverton, OR, USA / Oregon Health and Science University. Vaccine and Gene Therapy Institute. Portland, OR, USA.
Oregon Health and Science University. Vaccine and Gene Therapy Institute. Portland, OR, USA.
Oregon National Primate Research Center. Pathology Services Unit, Division of Comparative Medicine. Beaverton, OR, USA.
Oregon National Primate Research Center. Division of Pathobiology and Immunology. Beaverton, OR, USA.
Oregon National Primate Research Center. Division of Reproductive and Developmental Sciences. Beaverton, OR, USA.
Oregon National Primate Research Center. Division of Reproductive and Developmental Sciences. Beaverton, OR, USA / Oregon Health and Science University. Department of Obstetrics and Gynecology. Portland, OR, USA.
Oregon National Primate Research Center. Division of Reproductive and Developmental Sciences. Beaverton, OR, USA.
Oregon National Primate Research Center. Division of Pathobiology and Immunology. Beaverton, OR, USA / Oregon Health and Science University. Vaccine and Gene Therapy Institute. Portland, OR, USA.
Oregon National Primate Research Center. Division of Pathobiology and Immunology. Beaverton, OR, USA / Oregon Health and Science University. Vaccine and Gene Therapy Institute. Portland, OR, USA.
Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.
Universidade Federal da Bahia. Faculdade de Medicina. Instituto da Saúde Coletiva. Salvador, BA, Brasil.
University of California. California National Primate Research Center. Davis, Davis, CA, USA / University of California. School of Veterinary Medicine. Department of Pathology, Microbiology, and Immunology. Davis, Davis, CA, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, USA.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA / The Rockefeller University. Howard Hughes Medical Institute. New York, NY, USA.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA / Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.
Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven / Universidade Federal da Bahia. Faculdade de Medicina. Instituto da Saúde Coletiva. Salvador, BA, Brasil.
Fudan University. School of Basic Medical Sciences. Shanghai Medical College. Key Laboratory of Medical Molecular Virology. Shanghai, China.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven.
Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven.
Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.
Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil / Universidade Federal de São Paulo. São Paulo, SP, Brasil.
Universidade Federal da Bahia. Faculdade de Medicina. Instituto da Saúde Coletiva. Salvador, BA, Brasil.
Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.
Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.
Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.
Secretaria de Saúde do Estado da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Universidade Federal da Bahia. Faculdade de Medicina. Instituto da Saúde Coletiva. Salvador, BA, Brasil.
Ministério da Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Ministério da Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Ministério da Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY.
Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA.
Universidade Federal de São Paulo. São Paulo, SP, Brasil.
Hospital Santo Amaro. Salvador, BA, Brasil.
Hospital Santo Amaro. Salvador, BA, Brasil.
Hospital Santo Amaro. Salvador, BA, Brasil.
Hospital Aliança. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven / Universidade Federal da Bahia. Faculdade de Medicina. Instituto da Saúde Coletiva. Salvador, BA, Brasil.
University of California. California National Primate Research Center. Davis, Davis, CA, USA.
University of California. School of Veterinary Medicine. Department of Pathology, Microbiology, and Immunology. Davis, Davis, CA, USA.
Washington National Primate Research Center. Seattle, WA, USA / University of Washington. Center for Innate Immunity and Immune Disease. Seattle, WA, USA / University of Washington. Department of Immunology. Seattle, WA, USA.
Washington National Primate Research Center. Seattle, WA / University of Washington. Center for Innate Immunity and Immune Disease. Seattle, WA, USA / University of Washington. Department of Immunology. Seattle, WA, USA / University of Washington. Department of Global Health. Seattle, WA, USA.
University of Washington. Department of Global Health. Seattle, WA, USA / University of Washington. Department of Pediatrics. Seattle, WA, USA / Seattle Children’s Research Institute. Center for Global Infectious Disease Research. Seattle, WA, USA.
Washington National Primate Research Center. Seattle, WA, USA / University of Washington. Center for Innate Immunity and Immune Disease. Seattle, WA, USA / University of Washington. Department of Global Health. Seattle, WA, USA / University of Washington. Department of Obstetrics and Gynecology. Seattle, WA, USA.
University of Wisconsin-Madison. Department of Pathology and Laboratory Medicine. Madison, WI, USA.
University of Wisconsin-Madison. Wisconsin National Primate Research Center. Madison, WI, USA.
University of Wisconsin-Madison. Wisconsin National Primate Research Center. Madison, WI, USA.
University of Wisconsin-Madison. Department of Pathology and Laboratory Medicine. Madison, WI, USA.
Oregon National Primate Research Center. Division of Reproductive and Developmental Sciences. Beaverton, OR, USA.
Oregon National Primate Research Center. Division of Pathobiology and Immunology. Beaverton, OR, USA / Oregon Health and Science University. Vaccine and Gene Therapy Institute. Portland, OR, USA.
Oregon Health and Science University. Vaccine and Gene Therapy Institute. Portland, OR, USA.
Oregon National Primate Research Center. Pathology Services Unit, Division of Comparative Medicine. Beaverton, OR, USA.
Oregon National Primate Research Center. Division of Pathobiology and Immunology. Beaverton, OR, USA.
Oregon National Primate Research Center. Division of Reproductive and Developmental Sciences. Beaverton, OR, USA.
Oregon National Primate Research Center. Division of Reproductive and Developmental Sciences. Beaverton, OR, USA / Oregon Health and Science University. Department of Obstetrics and Gynecology. Portland, OR, USA.
Oregon National Primate Research Center. Division of Reproductive and Developmental Sciences. Beaverton, OR, USA.
Oregon National Primate Research Center. Division of Pathobiology and Immunology. Beaverton, OR, USA / Oregon Health and Science University. Vaccine and Gene Therapy Institute. Portland, OR, USA.
Oregon National Primate Research Center. Division of Pathobiology and Immunology. Beaverton, OR, USA / Oregon Health and Science University. Vaccine and Gene Therapy Institute. Portland, OR, USA.
Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.
Universidade Federal da Bahia. Faculdade de Medicina. Instituto da Saúde Coletiva. Salvador, BA, Brasil.
University of California. California National Primate Research Center. Davis, Davis, CA, USA / University of California. School of Veterinary Medicine. Department of Pathology, Microbiology, and Immunology. Davis, Davis, CA, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, USA.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA / The Rockefeller University. Howard Hughes Medical Institute. New York, NY, USA.
Abstract
Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015-2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.
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