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https://www.arca.fiocruz.br/handle/icict/36009
VERSICAN AND TUMOR-ASSOCIATED MACROPHAGES PROMOTES TUMOR PROGRESSION AND METASTASIS IN CANINE AND MURINE MODELS OF BREAST CARCINOMA
Angiogênese
Metástase pulmonar
Versican
Macrófagos associados a tumores
Author
Reis, Diego Carlos dos
Damasceno, Karine Araújo
Campos, Cecília Bonolo de
Veloso, Emerson Soares
Pêgas, Gabriela Rafaela Arantes
Kraemer, Lucas Rocha
Rodrigues, Michele Angela
Mattos, Matheus Silvério
Gomes, Dawidson Assis
Campos, Paula Peixoto
Ferreira, Enio
Russo, Remo Castro
Cassali, Geovanni Dantas
Damasceno, Karine Araújo
Campos, Cecília Bonolo de
Veloso, Emerson Soares
Pêgas, Gabriela Rafaela Arantes
Kraemer, Lucas Rocha
Rodrigues, Michele Angela
Mattos, Matheus Silvério
Gomes, Dawidson Assis
Campos, Paula Peixoto
Ferreira, Enio
Russo, Remo Castro
Cassali, Geovanni Dantas
Affilliation
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Institute of Biological Sciences. Laboratory of Pulmonary Immunology and Mechanics. Department of Physiology and Biophysics. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Laboratory of Pulmonary Immunology and Mechanics. Department of Physiology and Biophysics. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Laboratory of Pulmonary Immunology and Mechanics. Department of Physiology and Biophysics. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of Biochemistry and Immunology. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Laboratory of Pulmonary Immunology and Mechanics. Department of Physiology and Biophysics. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Laboratory of Pulmonary Immunology and Mechanics. Department of Physiology and Biophysics. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Laboratory of Pulmonary Immunology and Mechanics. Department of Physiology and Biophysics. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of Biochemistry and Immunology. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Laboratory of Pulmonary Immunology and Mechanics. Department of Physiology and Biophysics. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.
Abstract
Versican and tumor-associated macrophages (TAMs) are involved in growth and metastases in several cancers. Here, we investigated the potential role of versican, a matrix proteoglycan, and its correlation with TAMs infiltrates in different stages of two different breast cancer models: spontaneous canine mammary gland carcinomas and the murine 4T1 breast cancer model. The stromal versican expression was correlated with TAMs accumulation in tumors with an advanced stage from spontaneous canine mammary carcinoma samples. Versican expression in mice, identified in late stages of tumor progression, was associated to a high number of peri-tumoral infiltrating TAMs. Indeed, TAMs were related to a pro-inflammatory and pro-angiogenic state in the primary tumor. Furthermore, TAMs accumulation was related to versican expression in the lungs and an increased number of pulmonary metastatic nodules with pulmonary mechanical dysfunction, which was due to leukocyte influx in the airways and elevated growth factor levels in the microenvironment. Thus, we suggest that versican and TAMs as attractive targets for breast cancer therapy.
Keywords in Portuguese
Câncer de mamaAngiogênese
Metástase pulmonar
Versican
Macrófagos associados a tumores
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